Letter To The Editor
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2020; 26(34): 5220-5222
Published online Sep 14, 2020. doi: 10.3748/wjg.v26.i34.5220
Peliosis hepatis complicated by portal hypertension following renal transplantation
Grigory Demyashkin, Margarita Zatsepina
Grigory Demyashkin, Margarita Zatsepina, Department of Pathology, Sechenov University, Moscow 119146, Russia
Author contributions: Zatsepina M drafted and edited the manuscript; Demyashkin G revised and approved the final version of the manuscript.
Conflict-of-interest statement: No conflicts of interest, financial or otherwise, are declared by the authors.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Grigory Demyashkin, PhD, Assistant Professor, Department of Pathology, Sechenov University, Trubetskaya Street, 8/2, Moscow 119146, Russia. dr.dga@mail.ru
Received: May 22, 2020
Peer-review started: May 22, 2020
First decision: June 4, 2020
Revised: June 11, 2020
Accepted: August 26, 2020
Article in press: August 26, 2020
Published online: September 14, 2020
Abstract

Peliosis hepatis is a rare benign disease, but in last years the number of identified cases has increased. This disease is known to be sometimes accompanied by hepatocellular carcinoma. In the recent article, Yu et al describe a case of liver peliosis, characterized by an increased proliferative index. Therefore, additional diagnosis of patients should include analyzing other tumor markers expression in order to assess the risk of malignant cell transformation in peliosis hepatis.

Keywords: Peliosis hepatis, Hepatocellular carcinoma, Survivin, Epithelial-mesenchymal transition

Core Tip: Peliosis hepatis may be accompanied by malignant transformation. However, it remains unclear whether there is a pathogenetic relationship between these two conditions. The major purpose of this letter is to draw attention to the problem of timely diagnosis of carcinogenesis and prevention of tumor progression against the background of peliosis.