Published online Aug 7, 2018. doi: 10.3748/wjg.v24.i29.3204
Peer-review started: April 9, 2018
First decision: April 26, 2018
Revised: May 19, 2018
Accepted: June 27, 2018
Article in press: June 27, 2018
Published online: August 7, 2018
Helicobacter pylori (H. pylori) infection is very common and affects approximately half of the world population. It causes gastric diseases, but some authors have reported an association of H. pylori infection with other systemic manifestations beginning in 1994. The list of potential effects of H. pylori outside the stomach includes a number of extragastric manifestations and we focused on neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, allergic, and hepatobiliary diseases. This review discusses these important reported manifestations that are not related to the gastrointestinal tract.
Core tip:Helicobacter pylori (H. pylori) infection is a common infection that can cause gastric and extragastric diseases. A considerable amount of evidence links H. pylori infection with extragastric diseases, and in many of these diseases there is a clear beneficial effect of eradication therapy. This review summarizes the H. pylori-related extragastric manifestations of major interest that have been reported in the scientific literature, such as neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, allergic and hepatobiliary disease manifestations.