Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2018; 24(29): 3204-3221
Published online Aug 7, 2018. doi: 10.3748/wjg.v24.i29.3204
Helicobacter pylori and extragastric diseases: A review
Antonietta Gerarda Gravina, Rocco Maurizio Zagari, Cristiana De Musis, Lorenzo Romano, Carmelina Loguercio, Marco Romano
Antonietta Gerarda Gravina, Cristiana De Musis, Lorenzo Romano, Carmelina Loguercio, Marco Romano, Dipartimento di “Medicina di Precisione”, UOC Epatogastroenterologia, Università della Campania “Luigi Vanvitelli”, Napoli 80131, Italy
Rocco Maurizio Zagari, Dipertimento Di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna 40138, Italy
Author contributions: Gravina AG designed and wrote the manuscript; Zagari RM, Romano M and Loguercio C designed and revised the manuscript; De Musis C and Romano L contributed to the literature search. All authors equally contributed to this paper with the conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: The authors have no conflicts of interest and no financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Marco Romano, MD, PhD, Full Professor, Dipartimento di “Medicina di Precisione”, UOC Epatogastroenterologia, Università degli Studi della Campania “Luigi Vanvitelli”, Via Pansini, 5, Napoli 80131, Italy.
Telephone: +39-335-6768097
Received: April 9, 2018
Peer-review started: April 9, 2018
First decision: April 26, 2018
Revised: May 19, 2018
Accepted: June 27, 2018
Article in press: June 27, 2018
Published online: August 7, 2018

Helicobacter pylori (H. pylori) infection is very common and affects approximately half of the world population. It causes gastric diseases, but some authors have reported an association of H. pylori infection with other systemic manifestations beginning in 1994. The list of potential effects of H. pylori outside the stomach includes a number of extragastric manifestations and we focused on neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, allergic, and hepatobiliary diseases. This review discusses these important reported manifestations that are not related to the gastrointestinal tract.

Keywords: Helicobacter pylori, Extragastric disease, Neurological diseases, Dermatological diseases, Hematologic diseases, Ocular diseases, Cardiovascular diseases, Metabolic diseases, Allergic diseases, Hepatobiliary diseases

Core tip:Helicobacter pylori (H. pylori) infection is a common infection that can cause gastric and extragastric diseases. A considerable amount of evidence links H. pylori infection with extragastric diseases, and in many of these diseases there is a clear beneficial effect of eradication therapy. This review summarizes the H. pylori-related extragastric manifestations of major interest that have been reported in the scientific literature, such as neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, allergic and hepatobiliary disease manifestations.