Published online Feb 14, 2017. doi: 10.3748/wjg.v23.i6.1030
Peer-review started: December 6, 2016
First decision: December 20, 2016
Revised: December 27, 2016
Accepted: January 17, 2017
Article in press: January 17, 2017
Published online: February 14, 2017
To evaluate the effectiveness and tolerability of a split-dose 2 L polyethylene glycol (PEG)/ascorbic acid (AA) regimen for healthy examinees who visited for comprehensive medical check-up in the early morning.
From February 2015 to March 2015, examinees of average risk who were scheduled for a colonoscopy in the morning were retrospectively enrolled.
The 189 examinees were divided into split-dose and non-split-dose groups. The adequacy of bowel preparation for the split-dose group vs the non-split-dose group was 96.8% vs 85.2%, respectively, P < 0.001, and the compliance of the last meal restriction was 74.6% vs 58.2%, respectively, P < 0.001. The sleep disturbance (P < 0.001) was more prevalent in the split-dose group, however the willingness to repeat the same preparation method (P = 0.243) was not different in both groups. The split-dose regimen was the most important factor influencing adequate bowel preparation in multivariate analysis (HR = 10.89, 95%CI: 6.53-18.17, P < 0.001).
A split-dose regimen of 2 L PEG/AA for an early morning colonoscopy was more effective and showed better compliance for diet restriction without any difference in satisfaction and discomfort. Introducing a split-dose regimen of 2 L PEG/AA to morning colonoscopy examinees is effective and tolerable in a comprehensive medical check-up setting.
Core tip: A split-dose regimen of 2 L polyethylene glycol plus ascorbic acid is not widely used in comprehensive medical check-up, because this is considered intolerable for an early morning visit. We performed a retrospective cohort study to evaluate the effectiveness and tolerability of split-dose regimen for early morning visitors. A split-dose regimen for an early morning colonoscopy was more effective in bowel cleansing and showed better compliance for diet restriction compared with non-split-dose regimen without any difference in satisfaction and discomfort. Therefore, introducing a split-dose regimen to morning colonoscopy examinees is effective and tolerable even in comprehensive medical check-up settings.