Published online Oct 7, 2017. doi: 10.3748/wjg.v23.i37.6877
Peer-review started: June 12, 2017
First decision: July 13, 2017
Revised: August 15, 2017
Accepted: September 6, 2017
Article in press: September 5, 2017
Published online: October 7, 2017
To investigate the clinical utility of biological age (BA) measurement in screening colonoscopy for the detection of colorectal adenomas in the average-risk population.
A consecutive series of asymptomatic subjects aged ≥ 30 years who underwent colonoscopy in routine check-ups were enrolled. Colorectal adenoma was classified according to size, number, and location. BAs were calculated using the MEDIAGETM Biological Age Measurement System.
A total of 2696 subjects were investigated (1876 men and 820 women). The mean chronological age (CA) was 46.0 years and the mean BA was 44.7 years. Metabolic syndrome (MS) was diagnosed in 218 subjects (8.1%). The prevalence of overall colorectal adenoma was 23.1% (622/2,696). When the subjects were divided into four groups based on BA (≤ 39 years; 40-49 years; 50-59 years; ≥ 60 years), the prevalence of colorectal adenoma was increased as BA increased (P < 0.001). Colorectal adenoma located in the proximal colon was more prevalent in the BA-dominant group (BA-CA ≥ 5 years) than the CA-dominant group (CA-BA ≥ 5 years) (P = 0.034). When the subjects were categorized into four groups according to MS and age gap between BA and CA, the incidence of colorectal adenoma increased with MS and BA-dominance (P < 0.05).
Measurement of BA may help to assess the risk of colorectal adenoma in screening colonoscopy.
Core tip: The present study was conducted on the basis of the hypothesis that colorectal adenoma recognized as a premalignant lesion of colorectal cancer is associated with the biological aging process, suggesting that biological age (BA) represents a biological activity in human. Thus, we intended to assess the risk of colorectal adenomas in the average-risk population from the biological perspective. As a result, the present study demonstrated that the prevalence of colorectal adenoma correlated well with BA, and was more common in the distal colon in BA -dominance.