Review
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2017; 23(25): 4480-4490
Published online Jul 7, 2017. doi: 10.3748/wjg.v23.i25.4480
Expression and role of nuclear receptor coregulators in colorectal cancer
Mouna Triki, Marion Lapierre, Vincent Cavailles, Raja Mokdad-Gargouri
Mouna Triki, Marion Lapierre, Vincent Cavailles, IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, 34298 Montpellier, France
Mouna Triki, Raja Mokdad-Gargouri, Centre de Biotechnologie de Sfax, Université de Sfax, Sfax 3072, Tunisie
Author contributions: Triki M performed the literature review and analysis, wrote the manuscript and contributed to the generation of figures; Lapierre M and Mokdad-Gargouri R contributed to the drafting, editing and critical revision of the manuscript; Cavailles V designed the aim of the review, generated the figures and wrote the manuscript; all authors approved the final version.
Supported by SIRIC and the PHC-UTIQUE program, No. 16G 0805; PHC-UTIQUE program, No. 16G 0805; Tunisian government (Bourse d’alternance); INSERM, Université de Montpellier, INCa, SIRIC Montpellier, the Institut régional du Cancer de Montpellier.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Vincent Cavaillès, PhD, IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, 208 rue des apothicaires, 34298 Montpellier, France. vincent.cavailles@inserm.fr
Telephone: +33-4-67612405 Fax: +33-4-67613787
Received: August 2, 2016
Peer-review started: August 3, 2016
First decision: September 5, 2016
Revised: September 30, 2016
Accepted: October 31, 2016
Article in press: October 31, 2016
Published online: July 7, 2017
Processing time: 338 Days and 11.9 Hours
Abstract

Colorectal cancer (CRC) is one of the most common human cancers and the cause of about 700000 deaths per year worldwide. Deregulation of the WNT/β-catenin pathway is a key event in CRC initiation. This pathway interacts with other nuclear signaling pathways, including members of the nuclear receptor superfamily and their transcription coregulators. In this review, we provide an overview of the literature dealing with the main coactivators (NCoA-1 to 3, NCoA-6, PGC1-α, p300, CREBBP and MED1) and corepressors (N-CoR1 and 2, NRIP1 and MTA1) of nuclear receptors and summarize their links with the WNT/β-catenin signaling cascade, their expression in CRC and their role in intestinal physiopathology.

Keywords: Immunohistochemistry; Colon cancer; Nuclear receptors; Transcription coregulators; WNT signaling

Core tip: Colorectal cancer (CRC) is one of the most common human cancers worldwide. Deregulation of the WNT/β-catenin pathway is a key event in CRC initiation. This pathway interacts with other nuclear signaling pathways, including members of the nuclear receptor superfamily and their transcription coregulators. In this review, we provide an overview of the literature dealing with the main coactivators and corepressors of nuclear receptors, and summarize their links with the WNT/β-catenin signaling cascade, their expression in CRC and their role in intestinal physiopathology.