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World J Gastroenterol. Sep 14, 2016; 22(34): 7760-7766
Published online Sep 14, 2016. doi: 10.3748/wjg.v22.i34.7760
Long-term outcomes of autoimmune pancreatitis
Tsukasa Ikeura, Hideaki Miyoshi, Masaaki Shimatani, Kazushige Uchida, Makoto Takaoka, Kazuichi Okazaki
Tsukasa Ikeura, Hideaki Miyoshi, Masaaki Shimatani, Kazushige Uchida, Makoto Takaoka, Kazuichi Okazaki, Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Osaka 573-1010, Japan
Author contributions: Ikeura T, Miyoshi H and Shimatani M wrote the manuscript; Uchida K and Takaoka M made revision of the manuscript; Okazaki K made final approval of the manuscript to be published.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tsukasa Ikeura, MD, PhD, Department of Gastroenterology and Hepatology, Kansai Medical University, 2-3-1, Shinmachi, Hirakata, Osaka 573-1010, Japan. ikeurat@hirakata.kmu.ac.jp
Telephone: +81-72-8040101 Fax: +81-72-8042534
Received: March 28, 2016
Peer-review started: March 31, 2016
First decision: May 12, 2016
Revised: June 4, 2016
Accepted: June 28, 2016
Article in press: June 29, 2016
Published online: September 14, 2016
Processing time: 163 Days and 19.2 Hours
Abstract

Autoimmune pancreatitis (AIP) has been considered a favorable-prognosis disease; however, currently, there is limited information on natural course of AIP during long-term follow-up. Recently published studies regarding the long-term outcomes of AIP has demonstrated the developments of pancreatic stone formation, exocrine insufficiency, and endocrine insufficiency are observed in 5%-41%, 34%-82%, and 38%-57% of patients having the disease. Furthermore, the incidence rate of developing pancreatic cancer ranges from 0% to 4.8% during the long-term follow-up. The event of death from AIP-related complications other than accompanying cancer is likely to be rare. During follow-up of AIP patients, careful surveillance for not only relapse of the disease but also development of complications at regular intervals is needed.

Keywords: Autoimmune pancreatitis; Outcome; Cancer; Prognosis

Core tip: There is limited information on long-term outcomes of patients with autoimmune pancreatitis (AIP). This review provides a current overview of AIP regarding long-term outcomes such as pancreatic stone formation, pancreatic exocrine or endocrine dysfunction, associated malignancy, and mortality.