Published online Jun 28, 2016. doi: 10.3748/wjg.v22.i24.5495
Peer-review started: March 28, 2016
First decision: April 14, 2016
Revised: April 28, 2016
Accepted: May 21, 2016
Article in press: May 23, 2016
Published online: June 28, 2016
Endoscopic bariatric therapy may be a useful alternative to pharmacological treatment for obesity, and it provides greater efficacy with lower risks than do conventional surgical procedures. Among the various endoscopic treatments for obesity, the intragastric balloon is associated with significant efficacy in body weight reduction and relief of comorbid disease symptoms. Anatomically, this treatment is based on gastric space-occupying effects that increase the feeling of satiety and may also affect gut neuroendocrine signaling. The simplicity of the intragastric balloon procedure may account for its widespread role in obesity treatment and its applicability to various degrees of obesity. However, advances in device properties and procedural techniques are still needed in order to improve its safety and cost-effectiveness. Furthermore, verification of the physiological outcomes of intragastric balloon treatment and the clinical predictive factors for treatment responses should be considered. In this article, we discuss the types, efficacy, safety, and future directions of intragastric balloon treatment.
Core tip: Obesity is a complex metabolic illness that is associated with several comorbid diseases. There has been a constant demand for safe and more effective weight reduction interventions to fill the gap in the treatment of obesity. The intragastric balloon is a fascinating intermediate alternative solution between medical obesity treatment and bariatric surgical procedures for obese patients that may provide better efficacy and have a more favorable risk profile.