Clinical Trials Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2015; 21(47): 13339-13344
Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13339
Enhanced recovery after surgery with laparoscopic radical gastrectomy for stomach carcinomas
Ikram Abdikarim, Xue-Yuan Cao, Shou-Zhen Li, Yin-Quan Zhao, Yerlan Taupyk, Quan Wang
Ikram Abdikarim, Xue-Yuan Cao, Shou-Zhen Li, Yin-Quan Zhao, Yerlan Taupyk, Quan Wang, Department of Gastric and Colorectal Surgery, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Abdikarim I and Cao XY contributed equally to this work; Wang Q, Abdikarim I and Cao XY designed the study and carried out most of the research; Abdikarim I, Cao XY and Wang Q wrote the first draft, critically revised and approved the final version of the manuscript; Li SZ, Zhao YQ, and Taupyk Y provided valuable suggestions for the study.
Institutional review board statement: The study protocol was approved by the Ethical Committee of First Hospital of Jilin University.
Informed consent statement: Written informed consent was provided by all study participants prior to study enrollment.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Quan Wang, MD, PhD, Department of Gastric and Colorectal Surgery, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130021, Jilin Province, China.
Telephone: +86-431-81875617
Received: April 30, 2015
Peer-review started: May 7, 2015
First decision: July 10, 2015
Revised: July 27, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: December 21, 2015

AIM: To study the efficacy of the enhanced recovery after surgery (ERAS) program in laparoscopic radical gastrectomy for stomach carcinomas.

METHODS: From June 2010 to December 2012, 61 gastric cancer patients who underwent laparoscopic-assisted radical gastrectomy with D2 lymphadenectomy at First Hospital of Jilin University were enrolled in this randomized controlled trial. (Clinical, registration ID: NCT01955096). The subjects were divided into the ERAS program group and the conventional control group. The clinical characteristics, recovery variables, and complications of patients were analyzed.

RESULTS: The time to first ambulation, oral food intake, and time to defecation were significantly shorter in the ERAS group (n = 30), compared to the conventional group (n = 31; P = 0.04, 0.003, and 0.01, respectively). The postoperative hospital stay was less in the ERAS group (6.8 ± 1.1 d) compared to the conventional group (7.7 ± 1.1 d) (P = 0.002). There was no significant difference in postoperative complications between the ERAS (1/30) and conventional care groups (2/31) (P = 1.00). There were no readmissions or mortality during the 30-d follow-up period.

CONCLUSION: The ERAS program is associated with a shorter hospital stay in gastric cancer patients undergoing laparoscopic radical gastrectomy. The ERAS protocol is useful in the treatment of gastric cancer.

Keywords: Enhanced recovery after surgery, Laparoscopic, Gastrectomy, Gastric cancer

Core tip: This randomized controlled trial enrolled 61 consecutive laparoscopic-assisted gastrectomy patients, who were divided into the enhanced recovery after surgery (ERAS) group and the conventional group. Compared to the conventional group, the ERAS group showed earlier postoperative food intake, earlier defecation time, and shorter postoperative hospital stay. ERAS was safe and feasible in patients with advanced gastric cancers.