Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7608
Peer-review started: December 8, 2014
First decision: January 8, 2015
Revised: February 13, 2015
Accepted: March 18, 2015
Article in press: March 19, 2015
Published online: June 28, 2015
Duodenal adenocarcinoma, especially duodenal bulb with neuroendocrine features (NEF), is extremely rare. Here, we report one such case of duodenal bulb adenocarcinoma with neuroendocrine features. A 63-year-old Han Chinese woman was admitted to our department with the diagnosis of a duodenal bulb polyp and underwent an endoscopic mucosal resection. The pathological findings confirmed it as duodenal bulb adenocarcinoma with NEF. The patient remains curative after one and half a years of follow-up. Duodenal adenocarcinoma with NEF might be a low malignant neuroendocrine tumor rather than a conventional adenocarcinoma. Endoscopic treatment, including endoscopic mucosal resection, might be an ideal option for the adenocarcinomas with NEF.
Core tip: We report one extremely rare case of duodenal bulb adenocarcinoma with neuroendocrine features (NEF). Duodenal adenocarcinoma with NEF might be a low malignant neuroendocrine tumor rather than a conventional adenocarcinoma. Endoscopic treatment, including endoscopic mucosal resection, is plausibly an ideal option for adenocarcinomas with NEF.