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World J Gastroenterol. Feb 14, 2014; 20(6): 1537-1543
Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1537
Endoscopic papillectomy: Indications, techniques, and results
Giovanni D De Palma
Giovanni D De Palma, Center of Excellence for Technical Innovation in Surgery, Department of Clinical Medicine and Surgery, University of Naples Federico II School of Medicine, 80131 Naples, Italy
Author contributions: De Palma GD solely contributed to this paper.
Correspondence to: Giovanni D De Palma, MD, Director of Center of Excellence for Technical Innovation in Surgery, Department of Clinical Medicine and Surgery, University of Naples Federico II School of Medicine, Via Pansini 5, 80131 Naples, Italy. giovanni.depalma@unina.it
Telephone: +39-81-7462773 Fax: +39-81-7462752
Received: May 25, 2013
Revised: October 17, 2013
Accepted: December 12, 2013
Published online: February 14, 2014
Processing time: 273 Days and 17.2 Hours
Abstract

Endoscopic papillectomy (EP) is currently accepted as a viable alternative therapy to surgery in sporadic ampullary adenoma and has been reported to have high success and low recurrence rates. At present, the indications for EP are not yet fully established. The accepted criteria for EP include size (up to 5 cm), no evidence of intraductal growth, and no evidence of malignancy on endoscopic findings (ulceration, friability, and spontaneous bleeding). Endoscopic ultrasound (EUS) is the imaging modality of choice for local T staging in ampullary neoplasms. Data reported in the literature have revealed that linear EUS is superior to helical computed tomography in the preoperative assessment of tumor size, detection of regional nodal metastases and detection of major vascular invasion. Endoscopic ampullectomy is performed using a standard duodenoscope in a similar manner to snare polypectomy of a mucosal lesion. There is no standardization of the equipment or technique and broad EP methods are described. Endoscopic ampullectomy is considered a ‘‘high-risk’’ procedure due to complications. Complications of endoscopic papillectomy can be classified as early (pancreatitis, bleeding, perforation, and cholangitis) and late (papillary stenosis) complications. The appropriate use of stenting after ampullectomy may prevent post-procedural pancreatitis and papillary stenosis. Tumor recurrence of benign lesions occurs in up to 20% of patients and depends on tumor size, final histology, presence of intraductal tumor, coexisting familial adenomatous polyposis (FAP), and the expertise of the endoscopist. Recurrent lesions are usually benign and most can be retreated endoscopically.

Keywords: Endoscopic papillectomy; Papillary neoplasms; Major duodenal papilla; Endoscopic retrograde cholangiopancreatography; Endoscopic sphincterotomy

Core tip: Endoscopic papillectomy is a relatively safe and effective therapy and should be established as a first-line therapy for adenomas of the major duodenal papilla. Accurate staging of the tumor is important in the selection of patients. Performed by experienced endoscopists leads to successful tumor eradication in over 85% of patients with ampullary adenomas.