Brief Article
Copyright ©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Feb 7, 2014; 20(5): 1325-1331
Published online Feb 7, 2014. doi: 10.3748/wjg.v20.i5.1325
A new hemostatic clip for endoscopic surgery that can maintain blood flow after clipping
Kyoung Won Nam, Sang Bong Lee, In Young Kim, Kwang Gi Kim, Sang Jae Park
Kyoung Won Nam, In Young Kim, Department of Biomedical Engineering, Hanyang University, Seoul 133-791, South Korea
Kyoung Won Nam, Sang Bong Lee, Kwang Gi Kim, Biomedical Engineering Branch, National Cancer Center, Goyang 410-769, South Korea
Sang Jae Park, Center for Liver Cancer, National Cancer Center, Goyang 410-769, South Korea
Author contributions: Kim KG and Park SJ equally contributed to this paper; Nam KW and Lee SB designed the device and performed the research; Kim IY, Park SJ and Kim KG designed the research and contributed to the writing of the paper.
Supported by The National Cancer Center, South Korea, No. NCC-1210190
Correspondence to: Sang Jae Park, PhD, Center for Liver Cancer, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Goyang 410-769, South Korea. spark@ncc.re.kr
Telephone: +82-31-9201640 Fax: +82-31-9202006
Received: September 13, 2013
Revised: October 18, 2013
Accepted: November 12, 2013
Published online: February 7, 2014
Abstract

AIM: To develop a new hemostatic device for endoscopic surgery that can control the bleeding without completely occluding the bleeding vessel.

METHODS: A hemostatic clip and its applier that can stanch bleeding while maintaining blood flow through the clipped vessel was introduced, and the performance of the proposed clip was evaluated using in vitro and in vivo experiments.

RESULTS: During in vitro experiments, no leakage was found after clipping at cuts made in artificial vessels, and flow was maintained through the clipped artificial vessels. In experiments on rats, all the implanted clips occluded the target vessels successfully, and no bleeding or tissue damage was observed at the operative site after the rats were euthanized on postoperative day 7. In experiments on pigs, bleeding stopped immediately after partial clipping of a damaged vessel, and some amount of blood flow was consistently maintained through the clipped vessel after hemostasis.

CONCLUSION: We believe that the proposed hemostatic clip and clip applier can enhance patient safety during laparoscopic surgery.

Keywords: Vessel bleeding, Hemostasis, Hemostatic clip, Laparoscopic surgery, Endoscopic surgery

Core tip: This paper present a preclinical experimental study aimed at demonstrating the utility of a new clip designed to preserve blood flow while clipping a bleeding vessel. It can be a reasonable solution for partial large vessel injuries or avulsion injuries.