Retrospective Study
Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2014; 20(30): 10537-10544
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10537
Prognostic nutritional index predicts postoperative complications and long-term outcomes of gastric cancer
Nan Jiang, Jing-Yu Deng, Xue-Wei Ding, Bin Ke, Ning Liu, Ru-Peng Zhang, Han Liang
Nan Jiang, Jing-Yu Deng, Xue-Wei Ding, Bin Ke, Ning Liu, Ru-Peng Zhang, Han Liang, Key Laboratory of Cancer Prevention and Therapy, Department of Gastrointestinal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
Nan Jiang, Jing-Yu Deng, Xue-Wei Ding, Bin Ke, Ning Liu, Ru-Peng Zhang, Han Liang, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China
Author contributions: Jiang N, Liang H and Deng JY performed the majority of the study; Deng JY, Ding XW, Ke B, Liu N and Zhang RP designed the study and analyzed the data; Jiang N and Liang H wrote the manuscript; Deng JY and Ding XW revised the manuscript.
Supported by National Basic Research Program of China (973 Program), No. 2010CB529301; and the Key Program for Anti-cancer Research of Tianjin Municipal Science and Technology Commission, No. 12ZCDZSY16400
Correspondence to: Han Liang, MD, Key Laboratory of Cancer Prevention and Therapy, Department of Gastrointestinal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Ti-Yuan-Bei, Huan-Hu-Xi Road, He Xi District, Tianjin 300060, China. tjlianghan@gmail.com
Telephone: +86-22-23340123 Fax: +86-22-23340123
Received: December 16, 2013
Revised: March 12, 2014
Accepted: April 30, 2014
Published online: August 14, 2014
Abstract

AIM: To investigate the impact of prognostic nutritional index (PNI) on the postoperative complications and long-term outcomes in gastric cancer patients undergoing total gastrectomy.

METHODS: The data for 386 patients with gastric cancer were extracted and analyzed between January 2003 and December 2008 in our center. The patients were divided into two groups according to the cutoff value of the PNI: those with a PNI ≥ 46 and those with a PNI < 46. Clinicopathological features were compared between the two groups and potential prognostic factors were analyzed. The relationship between postoperative complications and PNI was analyzed by logistic regression. The univariate and multivariate hazard ratios were calculated using the Cox proportional hazard model.

RESULTS: The optimal cutoff value of the PNI was set at 46, and patients with a PNI ≥ 46 and those with a PNI < 46 were classified into PNI-high and PNI-low groups, respectively. Patients in the PNI-low group were more likely to have advanced tumor (T), node (N), and TNM stages than patients in the PNI-high group. The low PNI is an independent risk factor for the incidence of postoperative complications (OR = 2.223). The 5-year overall survival (OS) rates were 54.1% and 21.1% for patients with a PNI ≥ 46 and those with a PNI < 46, respectively. The OS rates were significantly lower in the PNI-low group than in the PNI-high group among patients with stages II (P = 0.001) and III (P < 0.001) disease.

CONCLUSION: The PNI is a simple and useful marker not only to identify patients at increased risk for postoperative complications, but also to predict long-term survival after total gastrectomy. The PNI should be included in the routine assessment of advanced gastric cancer patients.

Keywords: Prognostic nutritional index, Gastric cancer, Postoperative complications, Total gastrectomy, Prognosis

Core tip: Prognostic nutritional index (PNI) has been shown to be associated with poor outcomes in various types of malignancy. The low PNI was an independent risk factor for the incidence of postoperative complications and an independent predictor of poor overall survival (OS) in gastric cancer patients undergoing total gastrectomy. The OS rates were significantly lower in the PNI-low group than in the PNI-high group among patients with stages II and III disease. We suggest that PNI is a simple and useful marker not only to identify patients at increased risk for postoperative complications, but also to predict long-term survival after total gastrectomy.