Brief Article
Copyright ©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jan 21, 2014; 20(3): 804-813
Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.804
Systematic review: Laparoscopic fundoplication for gastroesophageal reflux disease in partial responders to proton pump inhibitors
Lars Lundell, Martin Bell, Magnus Ruth
Lars Lundell, Department of Surgery, CLINTEC, Karolinska Institutet, S141 86 Stockholm, Sweden
Martin Bell, Research Evaluation Unit, Oxford PharmaGenesis™ Ltd., Oxford, OX13 5QJ, United Kingdom
Magnus Ruth, Shire-Movetis NV, B-2300 Turnhout, Belgium
Author contributions: All authors contributed substantially to the conception and design of the study, analysis and interpretation of data, drafting and revision of the manuscript, and approved the final version of the manuscript.
Supported by AstraZeneca R and D, Mölndal, Sweden
Correspondence to: Lars Lundell, MD, Professor of Medicine, Department of Surgery, CLINTEC, Karolinska Institutet, S141 86 Stockholm, Sweden.
Telephone: +46-8-58580549 Fax: +46-8-58586366
Received: July 5, 2013
Revised: October 21, 2013
Accepted: November 13, 2013
Published online: January 21, 2014

AIM: To assess laparoscopic fundoplication (LF) in partial responders to proton pump inhibitors (PPIs) for gastroesophageal reflux disease (GERD).

METHODS: We systematically searched PubMed and Embase (1966-Dec 2011) for articles reporting data on LF efficacy in partial responders. Due to a lack of randomized controlled trials, observational studies were included. Of 558 articles screened, 17 were eligible for inclusion. Prevalence data for individual symptoms were collated across studies according to mutually compatible time points (before and/or after LF). Where suitable, prevalence data were presented as percentage of patients reporting symptoms of any frequency or severity.

RESULTS: Due to a lack of standardized reporting of symptoms, the proportion of patients experiencing symptoms was recorded across studies where possible. After LF, the proportion of partial responders with heartburn was reduced from 93.1% (5 studies) to 3.8% (5 studies), with similar results observed for regurgitation [from 78.4% (4 studies) to 1.9% (4 studies)]. However, 10 years after LF, 35.8% (2 studies) of partial responders reported heartburn and 29.1% (1 study) reported regurgitation. The proportion using acid-suppressive medication also increased, from 8.8% (4 studies) in the year after LF to 18.2% (2 studies) at 10 years. In the only study comparing partial responders to PPI therapy with complete responders, higher symptom scores and more frequent acid-suppressive medication use were seen in partial responders after LF.

CONCLUSION: GERD symptoms improve after LF, but subsequently recur, and acid-suppressive medication use increases. LF may be less effective in partial responders than in complete responders.

Keywords: Laparoscopic fundoplication, Gastroesophageal reflux disease, Partial response, Proton pump inhibitors, Systematic review

Core tip: There are no high-level evidence to support the use of laparoscopic fundoplication (LF) in partial responders to proton pump inhibitor (PPI) therapy. The evidence that does exist suggests LF improves symptom control in these patients, but symptoms recur over time. There are limited data to suggest that LF is not as efficacious in partial responders as in those with an adequate response to PPI therapy.