Irritable bowel syndrome: A concise review of current treatment concepts

Abstract

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders causing patients to seek medical treatment. It is relatively resource intensive and the source of significant morbidity. Recent insights into the pathophysiology and treatment of IBS has given clinicians more options than ever to contend with this disorder. The purpose of our paper is to review older, “classic” treatments for IBS as well as newer agents and “alternative” therapies. We discuss the evidence base of these drugs and provide context to help develop appropriate treatment plans for IBS patients.

Keywords: Irritable bowel syndrome, Probiotics, Rifaximin, Lubiprostone, Linaclotide, Peppermint oil

Core tip: Gastroenterology practitioners have more agents than ever before to treat the symptoms associated with irritable bowel syndrome. Unfortunately, despite advances in our understanding of the pathophysiology of this disorder, targeted treatments do not yet exist. This review summarizes the recent evidence-based treatment of this disorder, including, older and newer agents.