Clinical Articles
Copyright ©The Author(s) 1996. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 25, 1996; 2(2): 106-108
Published online Jun 25, 1996. doi: 10.3748/wjg.v2.i2.106
P53 and PCNA expression in glandular dilatation of gastric mucosa
Yang-Kun Wang, Xiao-Long Ji, You-Gui Gu, Shu-Chun Zhang, Jian-He Xiao
Yang-Kun Wang, You-Gui Gu, Shu-Chun Zhang, Jian-He Xiao, Department of Pathology, Chinese PLA 150 Hospital, Luoyang 471031, Henan Province, China
Xiao-Long Ji, Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China
Yang-Kun Wang, having 59 papers published
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Yang-Kun Wang, Department of Pathology, Chinese PLA 150 Hospital, Luoyang 471031, Henan Province, China
Received: October 20, 1995
Revised: February 10, 1996
Accepted: April 10, 1996
Published online: June 25, 1996
Abstract

AIM: To study the expression of p53 and PCNA in relation to gastric mucosa lesions.

METHODS: The S-P immunohistochemical method was used to observe 92 samples of glandular dilatation of gastric mucosa and 30 cases of adenocarcinoma of the stomach.

RESULTS: P53 showed no expression in simple glandular dilatation, but positive expression in a small number of cells in atypical glandular dilatation (< 8.6%, 5/58) as well as strong expression in gastric glandular cancer (< 46.7%, 14/30). There were a small number of PCNA positive cells in simple glandular dilatation, and a significant increase of positive cells in atypical glandular dilatation (P < 0.01); the positive cells were widely distributed and deeply stained in the cases of gastric cancer.

CONCLUSION: P53 and PCNA may be jointly used as an important criterion for diagnosing, classifying and treating the precancerous lesions of gastric mucosa.

Keywords: Gastric mucosa, Precancerous conditions, Stomach neoplasms, Adenocarcinoma, Genes, P53