Published online Jun 25, 1996. doi: 10.3748/wjg.v2.i2.106
Revised: February 10, 1996
Accepted: April 10, 1996
Published online: June 25, 1996
AIM: To study the expression of p53 and PCNA in relation to gastric mucosa lesions.
METHODS: The S-P immunohistochemical method was used to observe 92 samples of glandular dilatation of gastric mucosa and 30 cases of adenocarcinoma of the stomach.
RESULTS: P53 showed no expression in simple glandular dilatation, but positive expression in a small number of cells in atypical glandular dilatation (< 8.6%, 5/58) as well as strong expression in gastric glandular cancer (< 46.7%, 14/30). There were a small number of PCNA positive cells in simple glandular dilatation, and a significant increase of positive cells in atypical glandular dilatation (P < 0.01); the positive cells were widely distributed and deeply stained in the cases of gastric cancer.
CONCLUSION: P53 and PCNA may be jointly used as an important criterion for diagnosing, classifying and treating the precancerous lesions of gastric mucosa.