Published online Mar 25, 1996. doi: 10.3748/wjg.v2.i1.44
Revised: October 11, 1995
Accepted: December 16, 1995
Published online: March 25, 1996
AIM: To investigate the relationship between spleen deficiency substance, spleen deficiency and gastric cancer.
METHODS: We adopted the IBAS 2000 image analysis system and the 501B SEM with 9100/60 energy chromatic dispersing X-ray analysis instrument, along with histologic chemistry and radioimmunoassay to investigate the ultramicrostructure, intestinal metaplasia subtypes, cAMP, DNA, trace element series and their oxides of patients with gastric cancer.
RESULTS: The incidence rates of gastric cancer, incomplete colonic intestinal metaplasia (IM) and background lesion (P < 0.05 0.001). Additionally, the patients with incomplete IM and those with small bowel IM have lower levels of cAMP, Zn, Cu, ZnO and CuO and higher levels of p53 gene expression in gastric mucosa than patients with complete IM and those with colonic IM (P < 0.05-0.001). However, the levels of p53 DNA, cAMP, Zn, Cu, ZnO and CuO in gastric mucosa of incomplete colonic IM tissue are not remarkably different from those in gastric cancer tissue.
CONCLUSION: Gastric diseases in patients with spleen Qi deficiency or Qi stagnation have the tendency of turning into cancer. There is a close relationship between the incidence of incomplete colonic IM and gastric cancer.