Published online Mar 25, 1996. doi: 10.3748/wjg.v2.i1.25
Revised: October 31, 1995
Accepted: December 1, 1995
Published online: March 25, 1996
AIM: To determine the clinical significance of p53 protein expression in colorectal carcinoma.
METHODS: The expression of p53 protein was examined in 92 colorectal carcinomas using the monoclonal antibody PAb 1801. Correlation between p53 protein expression and prognosis in colorectal carcinoma was analyzed using the log-rank test.
RESULTS: The frequency of p53 protein expression was 57.61%, corresponding with Dukes' stage of bowel cancer. Analysis of survivor data demonstrated that the survival rate of the colorectal carcinoma with positive staining for p53 protein was lower than that of group with negative staining.
CONCLUSION: Expression of p53 protein is correlated with poor prognosis in colorectal carcinoma.