Case Report
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World J Gastroenterol. Feb 28, 2013; 19(8): 1314-1317
Published online Feb 28, 2013. doi: 10.3748/wjg.v19.i8.1314
Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression
Natsumi Kuwahara, Riko Kitazawa, Koto Fujiishi, Yusa Nagai, Ryuma Haraguchi, Sohei Kitazawa
Natsumi Kuwahara, Riko Kitazawa, Koto Fujiishi, Yusa Nagai, Ryuma Haraguchi, Sohei Kitazawa, Department of Molecular Pathology, Ehime University, Graduate School of Medicine, Ehime 791-0295, Japan
Author contributions: Kuwahara N, Kitazawa R, Fujiishi K, Nagai Y, Haraguchi R and Kitazawa S contributed to the manuscript writing and revision.
Supported by The Grant-in-Aid from Ministry of Education, Culture, Sports, Science and Technology, Japan
Correspondence to: Sohei Kitazawa, MD, PhD, Department of Molecular Pathology, Ehime University, Graduate School of Medicine, Shitsukawa 454, Toon City, Ehime 791-0295, Japan. kitazawa@m.ehime-u.ac.jp
Telephone: +81-89-9605264 Fax: +81-89-9605267
Received: November 2, 2012
Revised: December 19, 2012
Accepted: January 17, 2013
Published online: February 28, 2013
Abstract

Gastritis cystica profunda (GCP) is a rare condition caused by ectopic entrapment of gastric glands, probably secondary to the disruption of muscularis mucosae. GCP is often associated with gastric adenocarcinoma, and loss of the KCNE2 subunit from potassium channel complexes is considered a common primary target molecule leads to both GCP and malignancy. In this study, we, for the first time, analyzed the expression of KCNE2 in surgically excised tissue from human gastric cancer associated with GCP and confirmed that reduced KCNE2 expression correlates with disease formation.

Keywords: KCNE2, Gastritis cystica profunda, Immunohistochemistry