Published online Apr 7, 2013. doi: 10.3748/wjg.v19.i13.2129
Revised: March 2, 2013
Accepted: March 8, 2013
Published online: April 7, 2013
Hamaguchi et al recently reported some interesting observations on alcohol consumption and risk of fatty liver disease from a large population. However, we feel that it might be necessary to discuss some concerns in this study. As the alcohol consumption categorization was defined by the same criteria in both men and women, which might affect their results. As another factor is soft drinks consumption. It has been proved that soft drinks, especially fructose, contributes to the development of obesity, diabetes, metabolic syndrome, and nonalcoholic fatty liver disease. However, this confounding factor was not adjusted or discussed in this article. The third is the genetic background, for some genetic factors are related with the development of fatty liver disease, which was also not considered yet.
Core tip: Modest alcohol consumption was significantly inversely associated with fatty liver disease in recent studies. However, some studies did not consider some important potential confounding factors when they conclude their findings. Herein, we raised and discussed these important factors in this letter.