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©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
Is proliferative colonic disease presentation changing?
Vito D Corleto, Cristiano Pagnini, Maria Sofia Cattaruzza, Ermira Zykaj, Emilio Di Giulio, Giovanna Margagnoni, Emanuela Pilozzi, Giancarlo D’Ambra, Antonietta Lamazza, Enrico Fiori, Mario Ferri, Luigi Masoni, Vincenzo Ziparo, Bruno Annibale, Gianfranco Delle Fave
Vito D Corleto, Cristiano Pagnini, Ermira Zykaj, Emilio Di Giulio, Giovanna Margagnoni, Giancarlo D’Ambra, Mario Ferri, Luigi Masoni, Vincenzo Ziparo, Bruno Annibale, Gianfranco Delle Fave, Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sant’Andrea Hospital, “Sapienza” University, 00189 Rome, Italy
Maria Sofia Cattaruzza, Department of Public Health and Inf. Diseases, Faculty of Medicine, Policlinico Umberto I, “Sapienza” University, 00189 Rome, Italy
Emanuela Pilozzi, Department of Pathology, Faculty of Medicine and Psychology, Sant’Andrea Hospital, “Sapienza” University, 00189 Rome, Italy
Antonietta Lamazza, Enrico Fiori, Department of Surgery, Faculty of Medicine, Policlinico Umberto I, “Sapienza” University, 00189 Rome, Italy
Author contributions: Corleto VD designed the study, collected and elaborated the data; Corleto VD and Pagnini C wrote the manuscript; Corleto VD, Di Giulio E and D’Ambra G performed the colonoscopy and collected endoscopic data; Lamazza A, Fiori E, Ferri M, Masoni L and Ziparo V performed the surgery and collected surgical data; Pilozzi E collected and elaborated pathological data; Pagnini C, Zykaj E and Margagnoni G elaborated the data; Cattaruzza MS provided the statistical analysis of the data; Annibale B was involved in editing of the manuscript; and Delle Fave G contributed to the conception and coordinated the realization of the study.
Supported by Grants from “Ateneo Federato” University “La Sapienza” Rome, Italy, Year 2009 - Protocol C26F098MZM
Correspondence to: Vito D Corleto, MD, Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sant’Andrea Hospital, “Sapienza” University, Via di Grottarossa 1035, 00189 Rome, Italy. vito.corleto@uniroma1.it
Telephone: +39-6-33776152 Fax: +39-6-33776692
Received: February 28, 2012
Revised: June 19, 2012
Accepted: August 4, 2012
Published online: December 7, 2012
AIM: To compare the site, age and gender of cases of colorectal cancer (CRC) and polyps in a single referral center in Rome, Italy, during two periods.
METHODS: CRC data were collected from surgery/pathology registers, and polyp data from colonoscopy reports. Patients who met the criteria for familial adenomatous polyposis, hereditary non-polyposis colorectal cancer syndrome or inflammatory bowel disease were excluded from the study. Overlap of patients between the two groups (cancers and polyps) was carefully avoided. The χ2 statistical test and a regression analysis were performed.
RESULTS: Data from a total of 768 patients (352 and 416 patients, respectively, in periods A and B) who underwent surgery for cancer were collected. During the same time periods, a total of 1693 polyps were analyzed from 978 patients with complete colonoscopies (428 polyps from 273 patients during period A and 1265 polyps from 705 patients during period B). A proximal shift in cancer occurred during the latter years for both sexes, but particularly in males. Proximal cancer increased > 3-fold in period B compared to period A in males [odds ratio (OR) 3.31, 95%CI: 2.00-5.47; P < 0.0001). A similar proximal shift was observed for polyps, particularly in males (OR 1.87, 95%CI: 1.23-2.87; P < 0.0038), but also in females (OR 1.62, 95%CI: 0.96-2.73; P < 0.07).
CONCLUSION: The prevalence of proximal proliferative colonic lesions seems to have increased over the last decade, particularly in males.
