Brief Article
Copyright ©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Nov 7, 2012; 18(41): 5948-5956
Published online Nov 7, 2012. doi: 10.3748/wjg.v18.i41.5948
Electrogastrography associated with symptomatic changes after prokinetic drug treatment for functional dyspepsia
Hyun Chul Lim, Sang In Lee, Jiande DZ Chen, Hyojin Park
Hyun Chul Lim, Sang In Lee, Hyojin Park, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-752, South Korea
Jiande DZ Chen, Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, United States
Author contributions: Park H designed the research; Lim HC, Lee SI and Chen JDZ wrote the paper.
Correspondence to: Hyojin Park, MD, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-752, South Korea. hjpark21@yuhs.ac
Telephone: +82-2-20193310 Fax: +82-2-34633882
Received: February 20, 2012
Revised: June 7, 2012
Accepted: June 28, 2012
Published online: November 7, 2012
Abstract

AIM: To evaluate the effect of prokinetic drugs on electrogastrography (EGG) parameters according to symptomatic changes in patients with functional dyspepsia (FD).

METHODS: Seventy-four patients with FD were prospectively enrolled in this study between December 2006 and December 2010. We surveyed the patients using a questionnaire on dyspeptic symptoms before and after an 8-wk course of prokinetic drug treatment. We also measured cutaneous pre-prandial and post-prandial EGG recordings including percentage of gastric waves (normogastria, bradygastria, tachygastria), dominant frequency (DF), dominant power (DP), dominant frequency instability coefficient (DFIC), dominant power instability coefficient (DPIC), and the ratio of post-prandial to fasting in DP before and after the 8-wk course of prokinetic drug treatment.

RESULTS: Fifty-two patients (70%) achieved symptomatic improvement after prokinetic drug treatment. Patients who had normal gastric slow waves showed symptom improvement group after treatment. Post-prandial DF showed a downward trend in the symptom improvement group, especially in the itopride group. Post-prandial DP was increased regardless of symptom improvement, especially in the itopride group and mosapride group. Post-prandial DFIC and DPIC in the symptom improvement group were significantly increased after the treatment. The EGG power ratio was increased after treatment in the symptom improvement group (0.50 ± 0.70 vs 0.93 ± 1.77, P = 0.002), especially in the itopride and levosulpiride groups.

CONCLUSION: Prokinetics could improve the symptoms of FD by regulating gastric myoelectrical activity, and EGG could be a useful tool in evaluating the effects of various prokinetics.

Keywords: Electrogastrography; Functional dyspepsia; Itopride; Mosapride; Levosulpiride