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World J Gastroenterol. Jan 28, 2012; 18(4): 302-308
Published online Jan 28, 2012. doi: 10.3748/wjg.v18.i4.302
8-Hydroxydeoxyguanosine: Not mere biomarker for oxidative stress, but remedy for oxidative stress-implicated gastrointestinal diseases
Chan-Young Ock, Eun-Hee Kim, Duck Joo Choi, Ho Jae Lee, Ki-Baik Hahm, Myung Hee Chung
Chan-Young Ock, Eun-Hee Kim, Ho Jae Lee, Ki-Baik Hahm, Lab of Translational Medicine, Gachon University of Medicine and Science, Lee Gil Ya Cancer and Diabetes Institute, 7-45 Songdo-dong, Yeonsu-gu, 406-840 Incheon, South Korea
Duck Joo Choi, Ki-Baik Hahm, Department of Gastroenterology, Gachon Graduate School of Medicine, Gil Hospital, 1198 Guweol-dong, namdong-gu, 405-760 Incheon, South Korea
Myung Hee Chung, Sungkyunkwan University Samsung Advanced Institute for Biomedical Research, 50 Ilwon-dong, Kangnam-gu, 135-710 Seoul, South Korea
Author contributions: Ock CY and Kim EH contributed equally to this work; Choi DJ and Lee HJ advised the experiments and their results; Chung MH provided 8-OHdG as well as thoughtful advises; and Hahm KB and Ock CY wrote the paper.
Supported by A grant from the Ministry of Education and Science Technology, South Korea, No. 2010-0002052
Correspondence to: Ki-Baik Hahm, Professor, Lab of Translational Medicine, Gachon University of Medicine and Science, Lee Gil Ya Cancer and Diabetes Institute, 7-45 Songdo-dong, Yeonsu-gu, 406-840 Incheon, South Korea. hahmkb@gachon.ac.kr
Telephone: +82-32-8996055 Fax: +82-32-8996054
Received: May 16, 2011
Revised: August 26, 2011
Accepted: September 2, 2011
Published online: January 28, 2012

Reactive oxygen species (ROS) attack guanine bases in DNA easily and form 8-hydroxydeoxyguanosine (8-OHdG), which can bind to thymidine rather than cytosine, based on which, the level of 8-OHdG is generally regarded as a biomarker of mutagenesis consequent to oxidative stress. For example, higher levels of 8-OHdG are noted in Helicobacter pylori-associated chronic atrophic gastritis as well as gastric cancer. However, we have found that exogenous 8-OHdG can paradoxically reduce ROS production, attenuate the nuclear factor-κB signaling pathway, and ameliorate the expression of proinflammatory mediators such as interleukin (IL)-1, IL-6, cyclo-oxygenase-2, and inducible nitric oxide synthase in addition to expression of nicotinamide adenine dinucleotide phosphate oxidase (NOX)-1, NOX organizer-1 and NOX activator-1 in various conditions of inflammation-based gastrointestinal (GI) diseases including gastritis, inflammatory bowel disease, pancreatitis, and even colitis-associated carcinogenesis. Our recent finding that exogenous 8-OHdG was very effective in either inflammation-based or oxidative-stress-associated diseases of stress-related mucosal damage has inspired the hope that synthetic 8-OHdG can be a potential candidate for the treatment of inflammation-based GI diseases, as well as the prevention of inflammation-associated GI cancer. In this editorial review, the novel fact that exogenous 8-OHdG can be a functional molecule regulating oxidative-stress-induced gastritis through either antagonizing Rac-guanosine triphosphate binding or blocking the signals responsible for gastric inflammatory cascade is introduced.

Keywords: 8-hydroxydeoxyguanosine, Oxidative stress, Inflammation, Carcinogenesis, Prevention