Brief Article
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World J Gastroenterol. Aug 21, 2012; 18(31): 4207-4214
Published online Aug 21, 2012. doi: 10.3748/wjg.v18.i31.4207
X-ray repair cross-complementing group 1 polymorphisms and hepatocellular carcinoma: A meta-analysis
Tian Xie, Zhen-Guang Wang, Jing-Lei Zhang, Hui Liu
Tian Xie, Department of Hepatic Surgery, National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Central South University, Changsha 410008, Hunan Province, China
Zhen-Guang Wang, Jing-Lei Zhang, Hui Liu, Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
Author contributions: Xie T and Wang ZG contributed equally to this work; Liu H designed research; Xie T and Wang ZG performed the data search and meta-analysis; Zhang JL and Liu H wrote the paper.
Supported by International Science and Technology Cooperation Program of the Ministry of Science and Technology, No. 010S2012ZR0058; the National Basic Research Program of China, No. 2012CB526706; the Innovation Program of Shanghai Municipal Education Commission, No. 13ZZ060; the Fund of Shanghai Municipal Health Bureau, No. 2008Y077; and the Special Program for Military Medicine, No. 2010JS15
Correspondence to: Hui Liu, Associate Professor, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438 China.
Telephone: +86-21-65389998 Fax: +86-21-65562400
Received: March 20, 2012
Revised: May 14, 2012
Accepted: June 8, 2012
Published online: August 21, 2012

AIM: To perform a systematic meta-analysis to investigate the association between X-ray repair cross-complementing group 1 (XRCC1) polymorphisms and hepatocellular carcinoma (HCC) risk.

METHODS: Relevant studies extracted from PubMed, Embase, Wanfang, VIP and the Chinese National Knowledge Infrastructure databases up to March 2012 were included in the study. Stata software, version 11.0, was used for the statistical analysis. The odds ratios (ORs) and 95% confidence interval (CI) of the XRCC1 polymorphisms in HCC patients were analyzed and compared with healthy controls. The meta-analysis was performed using fixed-effect or random-effect methods, depending on the absence or presence of significant heterogeneity.

RESULTS: Eleven studies with 2075 HCC cases and 2604 controls met our eligibility criteria (four studies, 888 cases and 938 controls for Arg194Trp, four studies, 858 cases and 880 controls for Arg280His, and nine studies, 1845 cases and 2401 controls for Arg399Gln). The meta-analysis revealed no associations between the Arg194Trp and Arg399Gln polymorphisms of the XRCC1 gene and HCC risk under all contrast models (codominant, dominant and recessive models) in the overall analysis and sensitivity analysis (the studies with controls not in the Hardy-Weinberg equilibrium were excluded). For XRCC1 Arg280His polymorphism, the overall analysis revealed the significant association between the His/His genotype and the increased risk of HCC (His/His vs Arg/Arg model, OR: 1.96, 95% CI: 1.03-3.75, P = 0.04). However, sensitivity analysis showed an altered pattern of result and non-significant association (OR: 2.06, 95% CI: 0.67-6.25, P = 0.20). The heterogeneity hypothesis test did not reveal any heterogeneity, and Begg’s and Egger’s tests did not find any obvious publication bias.

CONCLUSION: The XRCC1 Arg194Trp and Arg399Gln polymorphisms are not associated with HCC risk. More rigorous association studies are needed to verify the involvement of XRCC1 Arg280His polymorphism in HCC susceptibility.

Keywords: X-ray repair cross-complementing group 1, Polymorphism, Hepatocellular carcinoma, Meta-analysis