Case Report
Copyright ©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Aug 14, 2012; 18(30): 4064-4068
Published online Aug 14, 2012. doi: 10.3748/wjg.v18.i30.4064
Rapidly deforming gastric carcinosarcoma with osteoblastic component: An autopsy case report
Hiroshi Yoshida, Noriyuki Tanaka, Naobumi Tochigi, Yoshio Suzuki
Hiroshi Yoshida, Noriyuki Tanaka, Naobumi Tochigi, Yoshio Suzuki, Department of Pathology, Asahi General Hospital, Chiba 289-2511, Japan
Author contributions: Yoshida H, Tanaka N, Tochigi N and Suzuki Y contributed equally to this work; all authors designed the research, provided discussion of the pathology and clinical features, and wrote of the paper
Correspondence to: Hiroshi Yoshida, MD, Chief Physician, Department of Pathology, Asahi General Hospital, i-1326 Asahi, Chiba 289-2511, Japan.
Telephone: +81-479-638111 Fax: +81-479-638580
Received: February 14, 2012
Revised: May 11, 2012
Accepted: May 26, 2012
Published online: August 14, 2012

Carcinosarcomas are rare, malignant, biphasic tumors simultaneously comprising carcinoma and sarcoma in a single tumor. We present an extremely rare case of gastric carcinosarcoma with an osteoblastic component that drastically changed its shape within 2 mo. A 59-year-old male patient presented to the emergency outpatient unit with a complaint of black stool. Gastrointestinal endoscopy showed an ulcerated mass in the cardia of the lesser curvature of the stomach. Biopsy specimens revealed only adenocarcinoma. Two months later, the ulcerated lesion drastically changed its shape into an exophytic tumor. Total gastrectomy was performed. In the resected specimen, the gastric tumor contained both adenocarcinoma and sarcoma components with lace-like osteoid. The patient died 7 mo after the operation, and an autopsy was performed. In the autopsy, widespread metastases were present in the liver, lung, lymph nodes and peritoneum. In this report, we describe a case of gastric carcinosarcoma and presume its tumorigenesis based on the autopsy findings.

Keywords: Carcinosarcoma, Stomach, Osteoblastic differentiation, Autopsy, Tumorigenesis