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©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
Effect of sumatriptan on gastric emptying: A crossover study using the BreathID system
Yasunari Sakamoto, Yusuke Sekino, Eiji Yamada, Takuma Higurashi, Hidenori Ohkubo, Eiji Sakai, Hiroki Endo, Hiroshi Iida, Takashi Nonaka, Koji Fujita, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Ayumu Goto, Yasunobu Abe, Eiji Gotoh, Shin Maeda, Atsushi Nakajima, Masahiko Inamori
Yasunari Sakamoto, Yusuke Sekino, Eiji Yamada, Takuma Higurashi, Hidenori Ohkubo, Eiji Sakai, Hiroki Endo, Hiroshi Iida, Takashi Nonaka, Koji Fujita, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Ayumu Goto, Yasunobu Abe, Shin Maeda, Atsushi Nakajima, Masahiko Inamori, Gastroenterology Division, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan
Eiji Gotoh, Department of Medical Education, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan
Masahiko Inamori, Office of Postgraduate Medical Education, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan
Author contributions: Sakamoto Y, Sekino Y, Nonaka T and Inamori M designed the study, performed the majority of the experiments and wrote the manuscript; Yoneda M, Koide T, Takahashi H and Goto A performed the statistical analyses; Abe Y, Gotoh E, Maeda S, Nakajima A and Inamori M provided analytical tools and were involved in editing the manuscript; Yamada E, Higurashi T, Ohkubo H, Sakai E, Endo H, Iida H and Fujita K analyzed the clinical data and participated in the design and coordination of the study.
Correspondence to: Dr. Masahiko Inamori, Gastroenterology Division, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan. inamorim@med.yokohama-cu.ac.jp
Telephone: +81-45-7872640 Fax: +81-45-7843546
Received: October 11, 2011
Revised: January 31, 2012
Accepted: April 10, 2012
Published online: July 14, 2012
AIM: To determine the effect of oral sumatriptan on gastric emptying using a continuous 13C breath test (BreathID system).
METHODS: Ten healthy male volunteers participated in this randomized, 2-way crossover study. The subjects fasted overnight and were randomly assigned to receive a test meal (200 kcal/200 mL) 30 min after pre-medication with sumatriptan 50 mg (sumatriptan condition), or the test meal alone (control condition). Gastric emptying was monitored for 4 h after administration of the test meal by the 13C-acetic acid breath test performed continually using the BreathID system. Then, using Oridion Research Software (β version), the time taken for emptying of 50% of the labeled meal (T1/2) similar to the scintigraphy lag time for 10% emptying of the labeled meal (Tlag), the gastric emptying coefficient (GEC), and the regression-estimated constants (β and κ) were calculated. The statistical significance of any differences in the parameters were analyzed using Wilcoxon’s signed-rank test.
RESULTS: In the sumatriptan condition, significant differences compared with the control condition were found in T1/2 [median 131.84 min (range, 103.13-168.70) vs 120.27 min (89.61-138.25); P = 0.0016], Tlag [median 80.085 min (59.23-125.89) vs 61.11 min (39.86-87.05); P = 0.0125], and β [median 2.3374 (1.6407-3.8209) vs 2.0847 (1.4755-2.9269); P = 0.0284]. There were no significant differences in the GEC or κ between the 2 conditions.
CONCLUSION: This study showed that oral sumatriptan significantly delayed gastric emptying of a liquid meal.
