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©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk
Mathilde Touvier, Léopold Fezeu, Namanjeet Ahluwalia, Chantal Julia, Nathalie Charnaux, Angela Sutton, Caroline Méjean, Paule Latino-Martel, Serge Hercberg, Pilar Galan, Sébastien Czernichow
Mathilde Touvier, Léopold Fezeu, Namanjeet Ahluwalia, Chantal Julia, Caroline Méjean, Paule Latino-Martel, Serge Hercberg, Pilar Galan, INSERM U557 (National Institute of Health and Medical Research), Inra, Cnam, University of Paris 13 (UREN), SMBH, 74 rue Marcel Cachin, F-93017 Bobigny, France
Nathalie Charnaux, Angela Sutton, Department of Biochemistry, Jean Verdier Hospital, F-93140 Bondy, France
Nathalie Charnaux, Angela Sutton, INSERM U698, University of Paris 13, F-93017 Bobigny, France
Serge Hercberg, Department of Public Health, Avicenne Hospital (AP-HP), University of Paris 13, F-93017 Bobigny, France
Sébastien Czernichow, Department of Nutrition, Ambroise Paré Hospital (AP-HP), University of Versailles Saint Quentin, F-92100 Boulogne-Billancourt, France
Author contributions: Touvier M and Czernichow S designed the research; Charnaux N, Sutton A, Hercberg S and Galan P collected the data; Touvier M analysed the data and drafted the manuscript; Touvier M, Fezeu L, Ahluwalia N, Julia C, Charnaux N, Sutton A, Méjean C, Latino-Martel P, Hercberg S, Galan P and Czernichow S interpreted the data, revised each draft and approved the final version of the manuscript.
Supported by A grant from the French National Cancer Institute (Institut National du Cancer), No. INCa 2007-1-SPC-3
Correspondence to: Dr. Mathilde Touvier, PhD, INSERM U557 (National Institute of Health and Medical Research), Inra, Cnam, University of Paris 13 (UREN), SMBH, 74 rue Marcel Cachin, F-93017 Bobigny, France. m.touvier@uren.smbh.univ-paris13.fr
Telephone: +33-1-48388954 Fax: +33-1-48388931
Received: July 12, 2011
Revised: December 14, 2011
Accepted: March 10, 2012
Published online: June 14, 2012
AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.
METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models.
RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%).
CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies.
