18F-fluoro-2-deoxyglucose uptake on PET CT and glucose transporter 1 expression in colorectal adenocarcinoma

doi:10.3748/wjg.v18.i2.168

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2012; 18(2): 168-174
Published online Jan 14, 2012. doi: 10.3748/wjg.v18.i2.168

¹⁸F-fluoro-2-deoxyglucose uptake on PET CT and glucose transporter 1 expression in colorectal adenocarcinoma

Ran Hong, Sung-Chul Lim

Ran Hong, Sung-Chul Lim, Department of Pathology and Research Center for Resistant cells, Medical School, Chosun University, Gwangju 501-140, South Korea

Author contributions: Hong R and Lim SC contributed equally to this work, including research design, data analysis, and writing and editing the manuscript.

Supported by National Research Foundation of Korea Grant funded by the Ministry of Education, Science and Technology through the Research Center for Resistant Cells, No. R13-2003-009

Correspondence to: Dr. Sung-Chul Lim, Department of Pathology and Research center for Resistant cells, Medical school, Chosun University, Gwangju 501-140, South Korea. sclim@chosun.ac.kr

Telephone: +82-62-2306343 Fax: +82-62-2344584

Received: April 19, 2011
Revised: June 27, 2011
Accepted: July 5, 2011
Published online: January 14, 2012

Abstract

AIM: To evaluate the correlation between the level of ¹⁸F-fluoro-2-deoxyglucose (¹⁸F-FDG) uptake and glucose transporter 1 (GLUT1) expression in colorectal adenocarcinoma (CRA).

METHODS: Forty four patients with resected CRA and preoperative ¹⁸F-FDG positron emission tomography - computed tomography data were investigated in this study. Comparison of maximum standardized uptake value (SUVmax) of the lesion was made with GLUT1 expression by immunohistochemistry and various clinicopathologic factors including tumor volume, invasion depth, gross finding, and lymph node metastasis.

RESULTS: SUVmax was 14.45 ± 7.0 in negative GLUT1 expression cases, 15.51 ± 5.7 in weak GLUT1 expression cases, and 16.52 ± 6.8 in strong GLUT1 expression cases, and there was no correlation between between GLUT1 expression and SUVmax. SUVmax was significantly correlated with tumor volume (P < 0.001). However, there was no significant differences in SUVmax and GLUT1 expression among other clinicopathologic factors.

CONCLUSION: GLUT1 expression does not correlates significantly with ¹⁸F-FDG uptake in CRA. ¹⁸F-FDG uptake was increased with tumor volume, which is statistically significant.

Keywords: ¹⁸F-fluoro-2-deoxyglucose, Glucose transporter 1, Colorectal cancer