Brief Article
Copyright ©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Feb 28, 2011; 17(8): 1058-1062
Published online Feb 28, 2011. doi: 10.3748/wjg.v17.i8.1058
Association between acute pancreatitis and peptic ulcer disease
Kang-Moon Lee, Chang-Nyol Paik, Woo Chul Chung, Jin Mo Yang
Kang-Moon Lee, Chang-Nyol Paik, Woo Chul Chung, Jin Mo Yang, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Gyeonggi-do 442-723, South Korea
Author contributions: Lee KM and Paik CN contributed to the study design, data interpretation, and wrote the manuscript; Chung WC and Yang JM contributed to the study design and critically reviewed the manuscript.
Correspondence to: Chang-Nyol Paik, MD, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, St. Vincent’s Hospital, Ji-dong, Paldal-gu, Suwon-si, Gyeonggi-do 442-723, South Korea. cmcu@catholic.ac.kr
Telephone: +82-31-2497138 Fax: +82-31-2538898
Received: August 19, 2010
Revised: September 26, 2010
Accepted: October 3, 2010
Published online: February 28, 2011
Abstract

AIM: To evaluate the relationship between peptic ulcer disease (PUD) and acute pancreatitis.

METHODS: A cohort of 78 patients with acute pancreatitis were included in this study. The presence of PUD and the Helicobacter pylori (H. pylori) status were assessed by an endoscopic method. The severity of acute pancreatitis was assessed using Ranson’s score, the Acute Physiology and Chronic Health Evaluation (APACHE) II score, computed tomography severity index and the clinical data during hospitalization, all of which were compared between the patients with and without PUD. The risk factors for PUD were also evaluated.

RESULTS: Among 78 patients, 41 patients (52.6%) with acute pancreatitis suffered from PUD, but only 13 (31.7%) patients with PUD were infected by H. pylori. On univariate analysis, male gender, an etiology of alcohol-induced pancreatitis, a history of smoking or alcohol consumption, elevated triglyceride and C-reactive protein levels, and high APACHE II score were significantly associated with PUD. However, on multivariate logistic regression analysis, the APACHE II score (odds ratio: 7.69; 95% confidence interval: 1.78-33.33; P < 0.01) was found to be the only independent risk factor for PUD.

CONCLUSION: Patients with acute pancreatitis are liable to suffer from PUD. PUD is associated with severe acute pancreatitis according to the APACHE II score, and treatment for PUD should be considered for patients with severe acute pancreatitis.

Keywords: Acute pancreatitis; Peptic ulcer disease; Helicobacter pylori; Acute Physiology and Chronic Health Evaluation II score