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World J Gastroenterol. Feb 14, 2011; 17(6): 804-808
Published online Feb 14, 2011. doi: 10.3748/wjg.v17.i6.804
HBV infection decreases risk of liver metastasis in patients with colorectal cancer: A cohort study
Hai-Bo Qiu, Li-Yi Zhang, Zhao-Lei Zeng, Zhi-Qiang Wang, Hui-Yan Luo, Rajiv Prasad Keshari, Zhi-Wei Zhou, Rui-Hua Xu
Hai-Bo Qiu, Zhao-Lei Zeng, Zhi-Qiang Wang, Hui-Yan Luo, Rajiv Prasad Keshari, Zhi-Wei Zhou, Rui-Hua Xu, State Key Laboratory of Oncology in South China, Guangzhou 510060, Guangdong Province, China
Hai-Bo Qiu, Zhi-Qiang Wang, Hui-Yan Luo, Rui-Hua Xu, Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China
Hai-Bo Qiu, Rajiv Prasad Keshari, Zhi-Wei Zhou, Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China
Li-Yi Zhang, Department of Clinical Oncology, University of HongKong, Pokfulam, HongKong, China
Zhao-Lei Zeng, Department of Research, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China
Author contributions: Qiu HB and Zhang LY contributed equally to this work; Qiu HB and Xu RH defined the research theme; Qiu HB, Zhang LY and Zeng ZL designed the methods and wrote the paper; Keshari RP revised the manuscript; Zhang LY, Wang ZQ and Luo HY analyzed the data and interpreted the results; Qiu HB and Zhou ZW collected, interpreted the data, and discussed the analyses; all authors approved the manuscript.
Supported by National Natural Science Foundation of China, No. 30672408
Correspondence to: Rui-Hua Xu, MD, PhD, Professor of Medical Oncology, Vice President, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China. xurh@sysucc.org.cn
Telephone: +86-20-87343468 Fax: +86-20-87343228
Received: October 7, 2010
Revised: November 8, 2010
Accepted: November 15, 2010
Published online: February 14, 2011
AIM: To evaluate the effect of hepatitis B virus (HBV) infection on liver metastasis of colorectal cancer.
METHODS: A total of 1298 colorectal cancer patients were recruited from January 2001 to March 2005 in this study. Enzyme-linked immunosorbent assay was used to test serum HBV markers for colorectal cancer. Patients were divided into study (infection) group and control (non-infection) group. Clinical features of patients in two groups were compared.
RESULTS: Liver metastasis was found in 319 out of the 1298 colorectal cancer patients. The incidence of liver metastasis was significantly lower in study group than in control group (14.2% vs 28.2%, P < 0.01). HBV infection significantly decreased the risk of liver metastasis [hazard ratio (HR): 0.50, 95% confidence interval (95% CI): 0.38-0.66], but the incidence of extrahepatic metastasis was significantly higher in study group than in control group (31.9% vs 17.0%, P < 0.01). The HR was the lowest in chronic hepatitis B group (HR: 0.29, 95% CI: 0.12-0.72). The number of liver metastatic lesions was significantly less in study group than in control group with a higher surgical resection rate. However, no significant difference was found in survival rate between the two groups (P = 0.95).
CONCLUSION: HBV infection decreases the risk of liver metastasis in patients with colorectal cancer and elevates the surgical resection rate of liver metastatic lesions.
