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World J Gastroenterol. Feb 7, 2011; 17(5): 677-680
Published online Feb 7, 2011. doi: 10.3748/wjg.v17.i5.677
Published online Feb 7, 2011. doi: 10.3748/wjg.v17.i5.677
In vivo characterization of DALM in ulcerative colitis with high-resolution probe-based confocal laser endomicroscopy
Giovanni D De Palma, Saverio Siciliano, Francesco Maione, Dario Esposito, Giovanni Persico, Department of Surgery and Advanced Technologies, Center of Excellence for Technical Innovation in Surgery, Section of Diagnostic and Therapeutic Endoscopy, University of Naples Federico II, School of Medicine, 80131, Naples, Italy
Stefania Staibano, Maria Siano, Department of Biomorphological and Functional Sciences, Section of Pathology, University of Naples Federico II, School of Medicine, 80131, Naples, Italy
Author contributions: De Palma GD and Staibano S contributed to conception and design, analysis and interpretation of data, drafting the article, critical revision of the article, final approval of the article; Siciliano S, Siano M, Esposito D and Maione F contributed to data gathering, analysis and interpretation of the data, drafting the article, final approval of the article; Persico G contributed to critical revision of the article and final approval of the article.
Correspondence to: Giovanni D De Palma, Professor, Department of Surgery and Advanced Technologies, Center of Excellence for Technical Innovation in Surgery, Section of Diagnostic and Therapeutic Endoscopy, University of Naples Federico II, School of Medicine, Via Pansini, 5, 80131, Naples, Italy. giovanni.depalma@unina.it
Telephone: +39-81-7462773 Fax: +39-81-7462752
Received: July 20, 2010
Revised: September 9, 2010
Accepted: September 16, 2010
Published online: February 7, 2011
Revised: September 9, 2010
Accepted: September 16, 2010
Published online: February 7, 2011
Abstract
Recently, the use of confocal laser endomicroscopy (CLE) in the diagnosis of chronic ulcerative colitis (CUC) was reported. In this brief report we aimed to assess the application of probe-based CLE to characterize colonic mucosa and dysplasia in CUC. The study involved a patient presenting long-standing CUC. Confocal imaging of both the inflamed mucosa, a circumscribed lesion (dysplasia-associated lesional mass), and adjacent colonic mucosa are demonstrated and the correlation between the CLE and histological images. Inflamed mucosa and dysplasia showed specific alteration of crypt architecture, cellular infiltration, and vessel architecture with an excellent correlation between CLE and standard histological examination.
Keywords: Colonoscopy, Confocal laser endomicroscopy, Chronic ulcerative colitis, Dysplasia-associated lesional mass, Histology