Scaldaferri F, Lancellotti S, Pizzoferrato M, Cristofaro RD. Haemostatic system in inflammatory bowel diseases: New players in gut inflammation. World J Gastroenterol 2011; 17(5): 594-608 [PMID: 21350708 DOI: 10.3748/wjg.v17.i5.594]
Corresponding Author of This Article
Raimondo De Cristofaro, MD, Professor, Department of Internal Medicine and Medical Specialties, Haemostasis Research Center, Catholic University of Rome, Largo Gemelli 8, 00168 Rome, Italy. rdecristofaro@rm.unicatt.it
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World J Gastroenterol. Feb 7, 2011; 17(5): 594-608 Published online Feb 7, 2011. doi: 10.3748/wjg.v17.i5.594
Haemostatic system in inflammatory bowel diseases: New players in gut inflammation
Franco Scaldaferri, Stefano Lancellotti, Marco Pizzoferrato, Raimondo De Cristofaro
Franco Scaldaferri, Marco Pizzoferrato, Department of Internal Medicine and Medical Specialties, Gastroenterology Division, Catholic University of Rome, 00168 Rome, Italy
Stefano Lancellotti, Raimondo De Cristofaro, Department of Internal Medicine and Medical Specialties, Haemostasis Research Center, Catholic University of Rome, 00168 Rome, Italy
Author contributions: All authors performed the literature revision and writing; Scaldaferri F and De Cristofaro R also revised and edited the paper.
Supported by Italian Ministry of University, No. PRIN-2007; and Catholic University School of Medicine, No. Linea D1-2009
Correspondence to: Raimondo De Cristofaro, MD, Professor, Department of Internal Medicine and Medical Specialties, Haemostasis Research Center, Catholic University of Rome, Largo Gemelli 8, 00168 Rome, Italy. rdecristofaro@rm.unicatt.it
Telephone: +39-6-30154438 Fax: +39-6-30155915
Received: January 25, 2010 Revised: March 25, 2010 Accepted: April 1, 2010 Published online: February 7, 2011
Abstract
Inflammation and coagulation constantly influence each other and are constantly in balance. Emerging evidence supports this statement in acute inflammatory diseases, such as sepsis, but it also seems to be very important in chronic inflammatory settings, such as inflammatory bowel disease (IBD). Patients with Crohn’s disease and ulcerative colitis have an increased risk of thromboembolic events, and several abnormalities concerning coagulation components occur in the endothelial cells of intestinal vessels, where most severe inflammatory abnormalities occur. The aims of this review are to update and classify the type of coagulation system abnormalities in IBD, and analyze the strict and delicate balance between coagulation and inflammation at the mucosal level. Recent studies on possible therapeutic applications arising from investigations on coagulation abnormalities associated with IBD pathogenesis will also be briefly presented and critically reviewed.
