Trapero-Marugán M, Mendoza J, Chaparro M, González-Moreno L, Moreno-Monteagudo JA, Borque MJ, Moreno-Otero R. Long-term outcome of chronic hepatitis C patients with sustained virological response to peginterferon plus ribavirin. World J Gastroenterol 2011; 17(4): 493-498 [PMID: 21274379 DOI: 10.3748/wjg.v17.i4.493]
Corresponding Author of This Article
Dr. María Trapero-Marugán, Gastroenterology-Hepatology Department, University Hospital La Princesa and Princesa Research Institute, Autonomous University of Madrid, and CIBERehd, C/Diego de León, 62, Third Floor, 28006 Madrid, Spain. mtraperomarugan@hotmail.com
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World J Gastroenterol. Jan 28, 2011; 17(4): 493-498 Published online Jan 28, 2011. doi: 10.3748/wjg.v17.i4.493
Long-term outcome of chronic hepatitis C patients with sustained virological response to peginterferon plus ribavirin
María Trapero-Marugán, Jorge Mendoza, María Chaparro, Leticia González-Moreno, José Andrés Moreno-Monteagudo, María Jesús Borque, Ricardo Moreno-Otero
María Trapero-Marugán, Jorge Mendoza, María Chaparro, Leticia González-Moreno, José Andrés Moreno-Monteagudo, María Jesús Borque, Ricardo Moreno-Otero, Gastroenterology-Hepatology Department, University Hospital La Princesa and Princesa Research Institute, Autonomous University of Madrid, and CIBERehd (Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas), 28006 Madrid, Spain
Author contributions: Trapero-Marugán M and Moreno-Otero R contributed equally to this work; Trapero-Marugán M and Moreno-Otero R designed the research, analyzed the data, and wrote the paper; Trapero-Marugán M, Mendoza J, Chaparro M, González-Moreno L, Moreno-Monteagudo JA, Borque MJ, Moreno-Otero R performed the research.
Supported by Instituto de Investigacion La Princesa and CIBERehd from Instituto de Salud Carlos III, Madrid, Spain
Correspondence to: Dr. María Trapero-Marugán, Gastroenterology-Hepatology Department, University Hospital La Princesa and Princesa Research Institute, Autonomous University of Madrid, and CIBERehd, C/Diego de León, 62, Third Floor, 28006 Madrid, Spain. mtraperomarugan@hotmail.com
Telephone: + 34-91-3093911 Fax: +34-91-4022299
Received: May 22, 2010 Revised: October 7, 2010 Accepted: October 14, 2010 Published online: January 28, 2011
Abstract
AIM: To assess the clinical, biochemical and virological long-term outcome in chronic hepatitis C (CHC) patients with a sustained virological response (SVR) after peginterferon (PEG-IFN) plus ribavirin combination therapy.
METHODS: One hundred and fifty three patients with a SVR after treatment with PEG-IFN plus ribavirin were included in a 5-year follow-up study in a single Spanish center, based on standard clinical practice. Clinical anamnesis, biochemical analysis, hepatitis C virus RNA and alpha-fetoprotein measurement, ultrasonography and transient elastography were performed annually.
RESULTS: The mean follow-up period of the 153 patients was 76 ± 13 mo after they obtained a SVR. Five patients (3.26%) presented with cirrhosis before treatment and 116 (75.8%) had genotype 1. No patient showed evidence of hepatic decompensation. One patient (0.65%) developed a hepatocellular carcinoma at month 30 after achieving SVR. There were no virological relapses during this follow-up period. Persistently elevated alanine aminotransferase was found in only one patient (0.65%). At the end of the 5-year follow-up, the mean value of transient elastography was 7 ± 4.3 kPa (F1). There were no deaths and no other tumors.
CONCLUSION: The long-term outcome of 153 CHC patients with SVR to PEG-IFN plus ribavirin was good. No evidence of a virological relapse was seen. One patient (0.65%) developed a hepatocellular carcinoma.
