Brief Article
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World J Gastroenterol. Sep 28, 2011; 17(36): 4113-4117
Published online Sep 28, 2011. doi: 10.3748/wjg.v17.i36.4113
Role of cyclooxygenase-2 gene polymorphisms in pancreatic carcinogenesis
Renata Talar-Wojnarowska, Anita Gasiorowska, Marek Olakowski, Pawel Lampe, Beata Smolarz, Hanna Romanowicz-Makowska, Ewa Malecka-Panas
Renata Talar-Wojnarowska, Anita Gasiorowska, Ewa Malecka-Panas, Department of Digestive Tract Diseases, Medical University, 22 Kopcinskiego, 90-153 Lodz, Poland
Marek Olakowski, Paweł Lampe, Department of Digestive Tract Surgery, Silesian Medical University, 14 Medykow, 40-752 Katowice, Poland
Beata Smolarz, Hanna Romanowicz-Makowska, Laboratory of Molecular Genetics, Institute of Polish Mother’s Memorial Hospital, 281/289 Rzgowska, 93-338 Lodz, Poland
Author contributions: Talar-Wojnarowska R and Gasiorowska A provided the protocols and performed the research; Olakowski M and Lampe P provided the collection of human material and analyzed the data; Smolarz B and Romanowicz-Makowska H carried out the molecular analysis; and Talar-Wojnarowska R and Malecka-Panas E designed the study and wrote the paper.
Correspondence to: Renata Talar-Wojnarowska, MD, PhD, Department of Digestive Tract Diseases, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, Poland.
Telephone: +48-42-6786480  Fax: +48-42-6786480
Received: December 20, 2010
Revised: March 26, 2011
Accepted: April 2, 2011
Published online: September 28, 2011

AIM: To evaluate the clinical significance of -765G/C and -1195G/A cyclooxygenase-2 (COX-2) gene polymorphisms in patients with pancreatic cancer (PC).

METHODS: The study included 201 patients: 85 with PC and 116 healthy controls. -765G/C and -1195G/A COX-2 gene polymorphisms were studied in DNA isolated from blood samples. The associations of the analyzed genotypes and clinical data at diagnosis were evaluated.

RESULTS: We found an increased frequency of the homozygous -1195AA COX-2 genotype in patients with PC (53.7%) compared with the control group (21%) (P < 0.01). In contrast, the distribution of genotype and allele frequencies of the -765G/C COX-2 polymorphism in the PC patients were not different from those in control groups. A correlation between presence of homozygous -1195AA COX-2 genotype and tumor size > 3 cm was observed (P < 0.05). Analyzed polymorphisms were unrelated to the patients’ sex and age, nor to the presence of regional or distant metastases.

CONCLUSION: These preliminary results indicate that the -1195G/A COX-2 polymorphism may play an important role in PC prognosis and carcinogenesis.

Keywords: Cyclooxygenase-2, Polymorphisms, Pancreatic cancer, Carcinogenesis