Brief Article
Copyright ©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Aug 14, 2011; 17(30): 3538-3543
Published online Aug 14, 2011. doi: 10.3748/wjg.v17.i30.3538
Propofol vs traditional sedative agents for endoscopic retrograde cholangiopancreatography: A meta-analysis
Lu-Long Bo, Yu Bai, Jin-Jun Bian, Ping-Shan Wen, Jin-Bao Li, Xiao-Ming Deng
Lu-Long Bo, Jin-Jun Bian, Ping-Shan Wen, Jin-Bao Li, Xiao-Ming Deng, Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, 200433 Shanghai, China
Yu Bai, Evidence-Based Medicine Group, Department of Gastroenterology, Changhai Hospital, Second Military Medical University, 200433 Shanghai, China
Author contributions: Bo LL, Bai Y and Bian JJ contributed equally to this work; Bo LL and Deng XM designed the research; Bo LL, Bai Y, Bian JJ, Wen PS and Li JB performed the research; Bo LL and Bai Y selected the studies and collected the data; Bian JJ, Wen PS and Li JB analyzed the data; Bo LL and Deng XM wrote the manuscript.
Supported by The grants from the Department of Anesthesiology and Intensive Care of Changhai Hospital, Shanghai, China
Correspondence to: Xiao-Ming Deng, MD, PhD, Professor of Anesthesiology, Chief, Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, 200433 Shanghai, China. deng_x@yahoo.com
Telephone: +86-21-81873484 Fax: +86-21-81873484
Received: November 6, 2010
Revised: January 18, 2011
Accepted: January 25, 2011
Published online: August 14, 2011
Abstract

AIM: To investigate the efficacy and safety of propofol sedation for endoscopic retrograde cholangiopancreatography (ERCP).

METHODS: Databases including PubMed, Embase, and the Cochrane Central Register of Controlled Trials updated as of October 2010 were searched. Main outcome measures were ERCP procedure duration, recovery time, incidence of hypotension and hypoxia.

RESULTS: Six trials with a total of 663 patients were included. The pooled mean difference in ERCP procedure duration between the propofol and traditional sedative agents was -8.05 (95% CI: -16.74 to 0.63), with no significant difference between the groups. The pooled mean difference in the recovery time was -18.69 (95% CI: -25.44 to -11.93), which showed a significant reduction with use of propofol sedation. Compared with traditional sedative agents, the pooled OR with propofol sedation for ERCP causing hypotension or hypoxia was 1.69 (95% CI: 0.82-3.50) and 0.90 (95% CI: 0.55-1.49), respectively, which indicated no significant difference between the groups.

CONCLUSION: Propofol sedation during ERCP leads to shorter recovery time without an increase of cardiopulmonary side effects. Propofol sedation can provide adequate sedation during ERCP.

Keywords: Endoscopic retrograde cholangiopancreatography; Propofol; Sedative agents; Meta-analysis; Outcomes