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©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
GST polymorphisms are associated with hepatocellular carcinoma risk in Chinese population
Lei Yu, Chun-Yu Wang, Bo Xi, Lei Sun, Ruo-Qi Wang, Yin-Kun Yan, Li-Ying Zhu
Lei Yu, Li-Ying Zhu, Department of Infectious Disease, the Fourth Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Chun-Yu Wang, Baylor College of Medicine and The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, United States
Bo Xi, Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan 250012, Shandong Province, China
Lei Sun, Department of Ophthalmology, the Fourth Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Ruo-Qi Wang, Department of Cardiology, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China
Yin-Kun Yan, Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China
Author contributions: Yu L, Wang CY and Xi B contributed equally to this work; Yu L, Wang CY, Xi B and Zhu LY designed the research; Yu L, Wang CY, Xi B, Sun L and Zhu LY performed the research; Wang RQ and Yan YK contributed samples/analytic tools; Yu L, Wang CY and Xi B analyzed the data; Wang CY and Xi B wrote the paper.
Supported by (partially) The Heilongjiang Provincial Health Department, No. 2009-201; and the Administration of Traditional Chinese Medicine of Heilongjiang Province, No. ZHY10-293
Correspondence to: Li-Ying Zhu, MD, PhD, Department of Infectious Disease, the Fourth Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China. zlyhmu@163.com
Telephone: +86-451-82576672 Fax: +86-451-82515767
Received: November 10, 2010
Revised: December 11, 2010
Accepted: December 18, 2010
Published online: July 21, 2011
AIM: To investigate the association between GSTM1 and GSTT1 polymorphisms and the risk of hepatocellular carcinoma (HCC) in Chinese population.
METHODS: Literature databases including PubMed, ISI web of science and other databases were searched. Pooled odds ratio (OR) and 95% CI were calculated using random- or fixed- effects model. Subgroup analysis and sensitivity analysis were also performed.
RESULTS: Nineteen studies of GSTM1 (2660 cases and 4017 controls) and 16 studies of GSTT1 (2410 cases and 3669 controls) were included. The GSTM1/GSTT1 null genotypes were associated with increased risk of HCC in Chinese population (for GSTM1, OR = 1.487, 95% CI: 1.159 to 1.908, P = 0.002; for GSTT1, OR = 1.510, 95% CI: 1.236 to 1.845, P = 0.000). No publication bias was detected. In subgroup analysis, glutathione S-transferases polymorphisms were significantly associated with HCC risk among the subjects living in high-incidence areas, but not among the subjects living in low-incidence areas.
CONCLUSION: The present meta-analysis suggests that GSTM1/GSTT1 null genotypes are associated with increased risk of HCC in Chinese population.
