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World J Gastroenterol. May 14, 2011; 17(18): 2259-2272
Published online May 14, 2011. doi: 10.3748/wjg.v17.i18.2259
Published online May 14, 2011. doi: 10.3748/wjg.v17.i18.2259
Recent advances in celiac disease
Hugh James Freeman, Division of Gastroenterology, University of British Columbia, Vancouver, BC, V6T 1W5, Canada
Angeli Chopra, Alan BR Thomson, Division of General Internal Medicine, University of Alberta, Edmonton, Alberta, AB T6G 2M7, Canada
Michael Tom Clandinin, Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, Alberta, AB T6G 2M7, Canada
Author contributions: Freeman HJ, Chopra A, Thomson ABR and Clandinin MT contributed equally to this work.
Correspondence to: Dr. Hugh James Freeman, Division of Gastroenterology, University of British Columbia, Vancouver, BC, V6T 1W5, Canada. hugfree@shaw.ca
Telephone: +1-604-8227216 Fax: +1-604-8227236
Received: January 6, 2011
Revised: February 12, 2011
Accepted: February 19, 2011
Published online: May 14, 2011
Revised: February 12, 2011
Accepted: February 19, 2011
Published online: May 14, 2011
Abstract
Celiac disease now affects about one person in a hundred in Europe and North America. In this review, we consider a number of important and exciting recent developments, such as clinical associations, HLA-DQ2 and HLA-DQ8 predispositions, the concept of potential celiac disease, the use of new imaging/endoscopy techniques, and the development of refractory disease. This review will be of use to all internists, pediatricians and gastroenterologists.
Keywords: Inflammation, Infection, Malabsorption, Pathophysiology, Physiology