Prevalence of occult hepatitis B virus infection

doi:10.3748/wjg.v17.i12.1538

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Mar 28, 2011 (publication date) through Apr 30, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2011; 17(12): 1538-1542
Published online Mar 28, 2011. doi: 10.3748/wjg.v17.i12.1538

Prevalence of occult hepatitis B virus infection

Maria Luisa Gutiérrez-García, Conrado M Fernandez-Rodriguez, Jose Luis Lledo-Navarro, Ingrid Buhigas-Garcia

Maria Luisa Gutiérrez-García, Conrado M Fernandez-Rodriguez, Jose Luis Lledo-Navarro, Ingrid Buhigas-Garcia, Service of Gastroenterology, Hospital Universitario Fundación Alcorcón, Av Budapest-1, 28922 Alcorcón, Madrid, Spain

Author contributions: Gutiérrez-García ML and Fernandez-Rodriguez CM contributed towards the conception and design of the review; Lledo-Navarro JL and Buhigas-Garcia I contributed equally to the supportive work and supervision.

Correspondence to: Maria Luisa Gutiérrez-García, MD, Service of Gastroenterology, Hospital Universitario Fundación Alcorcón, Av Budapest-1, 28922 Alcorcón, Madrid, Spain. mlgutierrez@fhalcorcon.es

Telephone: +34-91-6219513 Fax: +34-91-6219975

Received: August 6, 2010
Revised: November 16, 2010
Accepted: November 23, 2010
Published online: March 28, 2011

Abstract

Occult hepatitis B virus (HBV) infection (OBI) is characterized by the persistence of HBV DNA in the liver tissue in individuals negative for the HBV surface antigen. The prevalence of OBI is quite variable depending on the level of endemic disease in different parts of the world, the different assays utilized in the studies, and the different populations studied. Many studies have been carried out on OBI prevalence in different areas of the world and categories of individuals. The studies show that OBI prevalence seems to be higher among subjects at high risk for HBV infection and with liver disease than among individuals at low risk of infection and without liver disease.

Keywords: Occult hepatitis B virus infection, Hepatitis B virus DNA, Anti-HBc, Hepatitis B virus seronegative, Hepatitis C, Crytogenetic hepatitis, Dialysis, Human immunodeficiency virus, Blood donors