Brief Article
Copyright ©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Mar 14, 2011; 17(10): 1368-1372
Published online Mar 14, 2011. doi: 10.3748/wjg.v17.i10.1368
Efficacy of endoscopic therapy for gastrointestinal bleeding from Dieulafoy’s lesion
Jun Cui, Liu-Ye Huang, Yun-Xiang Liu, Bo Song, Long-Zhi Yi, Ning Xu, Bo Zhang, Cheng-Rong Wu
Jun Cui, Liu-Ye Huang, Yun-Xiang Liu, Bo Song, Long-Zhi Yi, Ning Xu, Bo Zhang, Cheng-Rong Wu, Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai 264000, Shandong Province, China
Author contributions: Cui J, Huang LY and Liu YX designed and initiated the study; Song B and Yi LZ performed a literature search; Xu N conducted additional cross searching; Cui J drafted and wrote the paper; Zhang B and Wu CR critically revised the paper.
Supported by Yantai City Science and Technology Development Plan, No. 2010148-13
Correspondence to: Dr. Jun Cui, Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai 264000, Shandong Province, China. cuijun89@163.com
Telephone: +86-535-6691999 Fax: +86-535-6240341
Received: November 18, 2010
Revised: December 1, 2010
Accepted: December 8, 2010
Published online: March 14, 2011
Abstract

AIM: To investigate the endoscopic hemostasis for gastrointestinal bleeding due to Dieulafoy’s lesion.

METHODS: One hundred and seven patients with gastrointestinal bleeding due to Dieulafoy’s lesion were treated with three endoscopic hemostasis methods: aethoxysklerol injection (46 cases), endoscopic hemoclip hemostasis (31 cases), and a combination of hemoclip hemostasis with aethoxysklerol injection (30 cases).

RESULTS: The rates of successful hemostasis using the three methods were 71.7% (33/46), 77.4% (24/31) and 96.7% (29/30), respectively, with significant differences between the methods (P < 0.05). Among those who had unsuccessful treatment with aethoxysklerol injection, 13 were treated with hemoclip hemostasis and 4 underwent surgical operation; 9 cases were successful in the injection therapy. Among the cases with unsuccessful treatment with hemoclip hemostasis, 7 were treated with injection of aethoxysklerol and 3 cases underwent surgical operation; 4 cases were successful in the treatment with hemoclip hemostasis. Only 1 case had unsuccessful treatment with a combined therapy of hemoclip hemostasis and aethoxysklerol injection, and surgery was then performed. No serious complications of perforation occurred in the patients whose bleeding was treated with the endoscopic hemostasis, and no re-bleeding was found during a 1-year follow-up.

CONCLUSION: The combined therapy of hemoclip hemostasis with aethoxysklerol injection is the most effective method for gastrointestinal bleeding due to Dieulafoy’s lesion.

Keywords: Dieulafoy’s lesion, Gastrointestinal bleeding, Endoscopic therapy, Aethoxysklerol, Therapeutic efficacy