Guiu B, Vincent J, Guiu S, Ladoire S, Ortega-Deballon P, Cercueil JP, Chauffert B, Ghiringhelli F. Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer. World J Gastroenterol 2010; 16(9): 1150-1154 [PMID: 20205288 DOI: 10.3748/wjg.v16.i9.1150]
Corresponding Author of This Article
Boris Guiu, MD, Department of Radiology, INSERM U866, University of Burgundy, University Hospital, Dijon, BP 87900 F-21079, France. boris.guiu@chu-dijon.fr
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Mar 7, 2010; 16(9): 1150-1154 Published online Mar 7, 2010. doi: 10.3748/wjg.v16.i9.1150
Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer
Boris Guiu, Julie Vincent, Séverine Guiu, Sylvain Ladoire, Pablo Ortega-Deballon, Jean-Pierre Cercueil, Bruno Chauffert, François Ghiringhelli
Boris Guiu, Jean-Pierre Cercueil, Department of Radiology, INSERM U866, University of Burgundy, University Hospital, Dijon, BP 87900 F-21079, France
Julie Vincent, Department of Hepatology, INSERM U866, University of Burgundy, University Hospital, Dijon, BP 87900 F-21079, France
Séverine Guiu, Sylvain Ladoire, Bruno Chauffert, François Ghiringhelli, Department of Oncology, INSERM U866, AVENIR Team, University of Burgundy, Georges-François Leclerc Cancer Center, Dijon, BP 87900 F-21000, France
Pablo Ortega-Deballon, Department of Digestive Surgery, INSERM U866, University of Burgundy, University Hospital, Dijon, BP 87900 F-21079, France
Author contributions: All authors contributed to the manuscript; Guiu B and Ghiringhelli F supervised the work.
Correspondence to: Boris Guiu, MD, Department of Radiology, INSERM U866, University of Burgundy, University Hospital, Dijon, BP 87900 F-21079, France. boris.guiu@chu-dijon.fr
Telephone: +33-380-293686 Fax: +33-380-295455
Received: September 1, 2009 Revised: October 22, 2009 Accepted: October 29, 2009 Published online: March 7, 2010
Abstract
Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease, resulting in increased local drug concentrations. Here we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic chemotherapy. The patient was treated with a combination of gemcitabine and oxaliplatin using HAI. The tolerance was excellent and a radiological complete response was obtained after 8 cycles of HAI. The rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this paper. HAI of gemcitabine-oxaliplatin should be evaluated in further clinical trials.
