Brief Article
Copyright ©2010 Baishideng. All rights reserved
World J Gastroenterol. Feb 14, 2010; 16(6): 740-744
Published online Feb 14, 2010. doi: 10.3748/wjg.v16.i6.740
Pericardiocentesis with cisplatin for malignant pericardial effusion and tamponade
Takatsugu Oida, Kenji Mimatsu, Hiso Kano, Atsushi Kawasaki, Youichi Kuboi, Nobutada Fukino, Sadao Amano
Takatsugu Oida, Kenji Mimatsu, Hiso Kano, Atsushi Kawasaki, Youichi Kuboi, Nobutada Fukino, Department of Surgery, Social Insurance Yokohama Central Hospital, 268 Yamashita-cho, Naka-ku, Yokohama 231-8553, Japan
Sadao Amano, Department of Surgery, Nihon University School of Medicine, 30-1 Kami-cho, Oyaguchi, Itabashi-ku, Tokyo 177-0023, Japan
Author contributions: Oida T, Mimatsu K, Kano H, Kawasaki A, Kuboi Y and Fukino N carried out the operation and were consultants overseeing the patient’s care; Oida T wrote the manuscript; Amano S drafted the manuscript and revised it critically.
Correspondence to: Takatsugu Oida, MD, PhD, Department of Surgery, Social Insurance Yokohama Central Hospital, 268 Yamashita-cho, Naka-ku, Yokohama 231-8553, Japan. ooida.takatsugu@yokochu.jp
Telephone: +81-45-6411921 Fax: +81-45-6719871
Received: October 22, 2009
Revised: November 24, 2009
Accepted: December 1, 2009
Published online: February 14, 2010
Abstract

AIM: To evaluate the role and outcome of pericardiocentesis with intrapericardial cisplatin instillation for malignant pericardial effusion resulting from esophageal cancer.

METHODS: We retrospectively studied 7 patients who underwent pericardiocentesis with intrapericardial cisplatin instillation for malignant pericardial effusion resulting from esophageal cancer. After pericardiocentesis, we performed catheterization of the pericardial space under ultrasonogram guidance. Malignant etiology of the pericardial fluid was confirmed by cytological examination. Subsequently, cisplatin (10 mg in 20 mL normal saline) was instilled into the pericardial space.

RESULTS: The mean total volume of the aspirated effusion fluid was 782 ± 264 mL (range, 400-1200 mL). The drainage catheter was successfully removed in all patients, and the mean duration of pericardial drainage was 7.7 ± 2.7 d (range, 5-13 d). No fluid reaccumulation was observed. Mean survival time was 120 ± 71 d (range, 68-268 d).

CONCLUSION: Pericardiocentesis along with catheter drainage appears to be a safe and effective for pericardial malignant effusion and tamponade, and cisplatin instillation prevents recurrence.

Keywords: Malignant pericardial effusion, Cardiac tamponade, Esophageal cancer, Pericardiocentesis, Cisplatin