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World J Gastroenterol. Dec 21, 2010; 16(47): 5907-5907
Published online Dec 21, 2010. doi: 10.3748/wjg.v16.i47.5907
Reverse cholesterol transport revisited
Astrid E van der Velde
Astrid E van der Velde, Academic Medical Center, AMC Liver Center, Meibergdreef 69-71, 1105 BK, Amsterdam, The Netherlands
Astrid E van der Velde, Department of Education and Development, Gelderse Vallei Hospital, 6710 HN Ede, The Netherlands
Author contributions: van der Velde AE solely contributed to this paper.
Correspondence to: Astrid E van der Velde, PhD, Department of Education and Development, Gelderse Vallei Hospital, PO Box 9025, 6710 HN Ede, The Netherlands. astridvandervelde@hotmail.com
Telephone: +31-318-891318 Fax: +31-318-436977
Received: July 2, 2010
Revised: August 25, 2010
Accepted: September 1, 2010
Published online: December 21, 2010

Reverse cholesterol transport was originally described as the high-density lipoprotein-mediated cholesterol flux from the periphery via the hepatobiliary tract to the intestinal lumen, leading to fecal excretion. Since the introduction of reverse cholesterol transport in the 1970s, this pathway has been intensively investigated. In this topic highlight, the classical reverse cholesterol transport concepts are discussed and the subject reverse cholesterol transport is revisited.

Keywords: Cholesterol, Reverse cholesterol transport, Transintestinal cholesterol efflux, Liver, Intestine, Lipoproteins