Sung CM, Hsu CM, Hsu JT, Yeh TS, Lin CJ, Chen TC, Su MY, Chiu CT. Predictive factors for lymph node metastasis in early gastric cancer. World J Gastroenterol 2010; 16(41): 5252-5256 [PMID: 21049560 DOI: 10.3748/wjg.v16.i41.5252]
Corresponding Author of This Article
Cheng-Tang Chiu, MD, Chief, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, 5 Fushing Street, Kweishan Shiang, Taoyuan 333, Taiwan, China. ctchiu@adm.cgmh.org.tw
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Chang-Mu Sung, Chen-Ming Hsu, Chun-Jung Lin, Ming-Yao Su, Cheng-Tang Chiu, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan, China
Jun-Te Hsu, Ta-Sen Yeh, Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan, China
Tse-Ching Chen, Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan, China
Author contributions: Chiu CT designed the research; Sung CM wrote the manuscript; Hsu JT, Hsu CM, Yeh TS, Lin CJ, Chen TC and Su MY provided the cases and suggestions; all authors read and approved the final manuscript.
Correspondence to: Cheng-Tang Chiu, MD, Chief, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, 5 Fushing Street, Kweishan Shiang, Taoyuan 333, Taiwan, China. ctchiu@adm.cgmh.org.tw
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Received: May 9, 2010 Revised: June 30, 2010 Accepted: July 7, 2010 Published online: November 7, 2010
Abstract
AIM: To analyze the predictive factors for lymph node metastasis (LNM) in early gastric cancer (EGC).
METHODS: Data from patients surgically treated for gastric cancers between January 1994 and December 2007 were retrospectively collected. Clinicopathological factors were analyzed to identify predictive factors for LNM.
RESULTS: Of the 2936 patients who underwent gastrectomy and lymph node dissection, 556 were diagnosed with EGC and included in this study. Among these, 4.1% of patients had mucosal tumors (T1a) with LNM while 24.3% of patients had submucosal tumors with LNM. Univariate analysis found that female gender, tumors ≥ 2 cm, tumor invasion to the submucosa, vascular and lymphatic involvement were significantly associated with a higher rate of LNM. On multivariate analysis, tumor size, lymphatic involvement, and tumor with submucosal invasion were associated with LNM.
CONCLUSION: Tumor with submucosal invasion, size ≥ 2 cm, and presence of lymphatic involvement are predictive factors for LNM in EGC.
