Akiyama T, Inamori M, Iida H, Endo H, Hosono K, Sakamoto Y, Fujita K, Yoneda M, Takahashi H, Koide T, Tokoro C, Goto A, Abe Y, Shimamura T, Kobayashi N, Kubota K, Saito S, Nakajima A. Shape of Barrett’s epithelium is associated with prevalence of erosive esophagitis. World J Gastroenterol 2010; 16(4): 484-489 [PMID: 20101776 DOI: 10.3748/wjg.v16.i4.484]
Corresponding Author of This Article
Masahiko Inamori, MD, PhD, Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. inamorim@med.yokohama-cu.ac.jp
Article-Type of This Article
Brief Article
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Tomoyuki Akiyama, Masahiko Inamori, Hiroshi Iida, Hiroki Endo, Kunihiro Hosono, Yasunari Sakamoto, Koji Fujita, Masato Yoneda, Hirokazu Takahashi, Tomoko Koide, Chikako Tokoro, Ayumu Goto, Yasunobu Abe, Takeshi Shimamura, Noritoshi Kobayashi, Kensuke Kubota, Satoru Saito, Atsushi Nakajima, Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
Author contributions: Akiyama T, Inamori M, Iida H, Endo H, Hosono K and Sakamoto Y designed the research; Akiyama T, Inamori M, Fujita K, Yoneda M, Takahashi H, Koide T and Tokoro C performed the research; Akiyama T, Inamori M, Goto A, Abe Y, Shimamura T, Kobayashi N and Kubota K analyzed the data; Akiyama T, Inamori M, Saito S and Nakajima A wrote the paper.
Correspondence to: Masahiko Inamori, MD, PhD, Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. inamorim@med.yokohama-cu.ac.jp
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Received: October 13, 2009 Revised: November 25, 2009 Accepted: December 2, 2009 Published online: January 28, 2010
Abstract
AIM: To test the hypothesis that the shape and length of Barrett’s epithelium are associated with prevalence of erosive esophagitis.
METHODS: A total study population comprised 869 patients who underwent endoscopy during a health checkup at our hospital. The presence and extent of Barrett’s epithelium were diagnosed based on the Prague C & M Criteria. We originally classified cases of Barrett’s epithelium into two types based on its shape, namely, flame-like and lotus-like Barrett’s epithelium, and into two groups based on its length, its C extent < 2 cm, and ≥ 2 cm. Correlation of shape and length of Barrett’s epithelium with erosive esophagitis was examined.
RESULTS: Barrett’s epithelium was diagnosed in 374 cases (43%). Most of these were diagnosed as short-segment Barrett’s epithelium. The prevalence of erosive esophagitis was significantly higher in subjects with flame-like than lotus-like Barrett’s epithelium, and in those with a C extent of ≥ 2 cm than < 2 cm.
CONCLUSION: Flame-like rather than lotus-like Barrett’s epithelium, and Barrett’s epithelium with a longer segment were more strongly associated with erosive esophagitis.
