Brief Article
Copyright copy;2010 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Oct 21, 2010; 16(39): 4944-4951
Published online Oct 21, 2010. doi: 10.3748/wjg.v16.i39.4944
Pancreatic function, quality of life and costs at long-term follow-up after acute pancreatitis
Bodil Andersson, Marie-Louise Pendse, Roland Andersson
Bodil Andersson, Marie-Louise Pendse, Roland Andersson, Department of Surgery, Clinical Siences Lund, Lund University and Lund University Hospital, S-221 85 Lund, Sweden
Author contributions: Andersson B and Andersson R designed the research; Andersson B and Pendse ML performed the research; Andersson B analyzed the data and wrote the paper.
Supported by Skane county council research and development foundation
Correspondence to: Bodil Andersson, MD, PhD, Department of Surgery, Clinical Sciences Lund, Lund University and Lund University Hospital, S-221 85 Lund, Sweden.
Telephone: +46-46-172757 Fax: +46-46-147298
Received: May 9, 2010
Revised: June 3, 2010
Accepted: June 10, 2010
Published online: October 21, 2010

AIM: To evaluate long-term endocrine and exocrine pancreatic function, quality of life and health care costs after mild acute pancreatitis and severe acute pancreatitis (SAP).

METHODS: Patients prospectively included in 2001-2005 were followed-up after 42 (36-53) mo. Pancreatic function was evaluated with laboratory tests, the oral glucose tolerance test (OGTT), fecal elastase-1 and a questionnaire. Short Form (SF)-36, was completed.

RESULTS: Fourteen patients with a history of SAP and 26 with mild acute pancreatitis were included. Plasma glucose after OGTT was higher after SAP (9.2 mmol/L vs 7.0 mmol/L, P = 0.044). Diabetes mellitus or impaired glucose tolerance in fasting plasma glucose and/or 120 min plasma glucose were more common in SAP patients (11/14 vs 11/25, P = 0.037). Sick leave, time until the patients could take up recreational activities and time until they had recovered were all longer after SAP (P < 0.001). No significant differences in SF-36 were seen between the groups, or when comparing with age and gender matched reference groups. Total hospital costs, including primary care, follow-up and treatment of complications, were higher after SAP (median €16 572 vs€5000, P < 0.001).

CONCLUSION: Endocrine pancreatic function was affected, especially after severe disease. SAP requires greater resource use with long recovery, but most patients regained a good quality of life.

Keywords: Acute pancreatitis, Endocrine function, Exocrine function, Quality of life, Cost