Brief Article
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World J Gastroenterol. Oct 7, 2010; 16(37): 4709-4715
Published online Oct 7, 2010. doi: 10.3748/wjg.v16.i37.4709
Usefulness of magnifying endoscopy for iodine-unstained lesions in a high-risk esophageal cancer population
Ik Seong Choi, Jae Young Jang, Won Young Cho, Tae Hee Lee, Hyun Gun Kim, Bo Young Lee, Soung Won Jeong, Joo Young Cho, Joon Seong Lee, So Young Jin
Ik Seong Choi, Jae Young Jang, Won Young Cho, Tae Hee Lee, Hyun Gun Kim, Bo Young Lee, Soung Won Jeong, Joo Young Cho, Joon Seong Lee, So Young Jin, Institute for Digestive Research, SoonChunHyang University College of Medicine, Seoul 140-743, South Korea
Author contributions: Choi IS and Jang JY contributed equally to this work; Jang JY, Cho WY, Lee TH, Kim HG, Lee BY, Jeong SW, Cho JY and Lee JS provides clinical advice; Choi IS, Jang JY, Cho JY and Jin SY performed the research; Choi IS and Jang JY wrote the paper.
Correspondence to: Joo Young Cho, MD, PhD, Professor, Institute for Digestive Research, SoonChunHyang University College of Medicine, 657 Hannamdong, Yongsangu, Seoul 140-743, South Korea. cjy6695@dreamwiz.com
Telephone: +82-2-7099202 Fax: +82-2-7099696
Received: April 27, 2010
Revised: May 20, 2010
Accepted: May 27, 2010
Published online: October 7, 2010
Abstract

AIM: To investigate the usefulness of magnified observations of iodine-unstained esophageal lesions in the histological diagnosis of esophageal mucosa abnormalities, in high-risk esophageal cancer groups.

METHODS: The subjects included 38 patients who had at least one of the four criteria known to be high-risk factors for esophageal cancer. Following endoscopic observation, magnified observations were performed on iodine-unstained lesions of the esophagus. The total number of lesions was 43. These lesions were classified as type A (clear papilla), type B (fused papilla), and type C (non-visible papilla) according to the findings. Tissue biopsy was then carried out. Finally the histological findings were graded in terms of histological factors, and their relationships were compared.

RESULTS: Of the 43 lesions, 11 were type A, 17 were type B, and 15 were type C under magnifying endoscopy. Histological findings such as inflammatory cell infiltration and basal cell hyperplasia were significantly increased in type B and type C lesions compared with type A lesions (P < 0.05). Low-grade esophageal dysplasia was apparent in 1 (9%) of 11 type A lesions, in 3 (18%) of 17 type B lesions, and in 6 (40%) of 15 type C lesions, with the highest rate in type C.

CONCLUSION: Magnified observations of the esophagus, classified by papillary aspects using magnifying endoscopy of iodine-unstained lesions in high-risk esophageal cancer groups, are considered useful in estimating dysplasia and inflammation of esophageal mucosa.

Keywords: Esophageal cancer; Iodine; Magnifying endoscopy