Brief Article
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World J Gastroenterol. Sep 28, 2010; 16(36): 4611-4615
Published online Sep 28, 2010. doi: 10.3748/wjg.v16.i36.4611
High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients
Jian-Cong Sun, Xiao-Ting Liang, Ke Pan, Hui Wang, Jing-Jing Zhao, Jian-Jun Li, Hai-Qing Ma, Yi-Bing Chen, Jian-Chuan Xia
Jian-Cong Sun, Xiao-Ting Liang, Ke Pan, Hui Wang, Jing-Jing Zhao, Jian-Jun Li, Hai-Qing Ma, Yi-Bing Chen, Jian-Chuan Xia, State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong Province, China
Author contributions: Xia JC, Sun JC and Pan K designed the experiments; Sun JC, Liang XT, Wang H and Zhao JJ performed the majority of experiments; Sun JC, Li JJ, Ma HQ and Chen YB analyzed the data; Sun JC and Xia JC wrote the paper.
Supported by National Natural Science Foundation of China, No. u0772002
Correspondence to: Dr. Jian-Chuan Xia, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, 651 Dongfeng East Road, Guangzhou 510060, Guangdong Province, China. xiajch@mail.sysu.edu.cn
Telephone: +86-20-87343173 Fax: +86-20-87343392
Received: May 1, 2010
Revised: June 10, 2010
Accepted: June 17, 2010
Published online: September 28, 2010
Abstract

AIM: To determine the role of epidermal growth factor-like repeats and discoidin I-like domains 3 (EDIL3) in pathogenesis of hepatocellular carcinoma (HCC) by investigating the EDIL3 expression in HCC and its prognostic value for HCC.

METHODS: EDIL3 expression was detected in 101 HCC surgical tissue samples with immunohistochemistry method, and its relation with clinicopathologic features and prognosis of HCC patients was analyzed.

RESULTS: EDIL3 was highly expressed in 48.5% of the HCC patients. Although the EDIL3 expression level did not correlate with any clinicopathological parameters, Kaplan-Meier survival analysis showed that high expression level of EDIL3 resulted in a significantly poor prognosis of HCC patients (log-rank test, P = 0.010). Multivariate Cox’s analysis showed that the EDIL3 expression level was a significant and independent prognostic parameter for the overall survival rate of HCC patients (hazard ratio = 1.978, 95% confidence interval = 1.139-3.435, P = 0.015).

CONCLUSION: High expression level of EDIL3 predicts poor prognosis of HCC patients. EDIL3 may be a potential target of antiangiogenic therapy for HCC.

Keywords: Epidermal growth factor-like repeats and discoidin I-like domains 3, Hepatocellular carcinoma, Prognosis, Angiogenesis