Brief Article
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World J Gastroenterol. Sep 28, 2010; 16(36): 4583-4588
Published online Sep 28, 2010. doi: 10.3748/wjg.v16.i36.4583
Clinicopathological evaluation of duodenal well-differentiated endocrine tumors
Kenji Ishido, Satoshi Tanabe, Katsuhiko Higuchi, Tohru Sasaki, Chikatoshi Katada, Mizutomo Azuma, Akira Naruke, Wasaburo Koizumi, Tetsuo Mikami
Kenji Ishido, Satoshi Tanabe, Katsuhiko Higuchi, Tohru Sasaki, Chikatoshi Katada, Mizutomo Azuma, Akira Naruke, Wasaburo Koizumi, Department of Gastroenterology, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, Japan
Tetsuo Mikami, Department of Pathology, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, Japan
Author contributions: Ishido K and Tanabe S contributed equally to this work; Ishido K, Tanabe S, Higuchi K, Sasaki T, Katada C, Azuma M, Naruke A, Koizumi W and Mikami T designed research and were also involved in editing the manuscript.
Correspondence to: Dr. Kenji Ishido, Department of Gastroenterology, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, Japan. k.ishido@kitasato-u.ac.jp
Telephone: +81-42-7489111 Fax: +81-42-7498690
Received: May 2, 2010
Revised: June 19, 2010
Accepted: June 26, 2010
Published online: September 28, 2010
Abstract

AIM: To assess the clinicopathological characteristics of duodenal well-differentiated endocrine tumors.

METHODS: We examined clinicopathological characteristics in 11 consecutive patients with duodenal well-differentiated endocrine tumors treated by endoscopic therapy or surgery in our hospital from 1992 through 2007. Patients with well-differentiated endocrine tumors of the papilla of Vater or with gastrinoma were excluded.

RESULTS: Three patients received endoscopic treatment, and 8 underwent surgery. In patients who received endoscopic treatment, the tumor diameter was less than 1.0 cm, with no histopathological evidence of lymphovascular invasion or invasion of the muscularis. There were no complications such as late bleeding or perforation after treatment. Among 8 patients with tumors less than 1.0 cm in diameter, 3 underwent partial resection, and 2 underwent radical surgery. Three patients had lymphovascular invasion, 1 had invasion of the muscularis, and 1 had proximal lymph node metastasis. Among 3 patients with tumors 1.0 cm or more in diameter, 1 underwent partial resection, and 2 underwent radical surgery. One patient had lymphovascular invasion, with no lymph node metastasis. After treatment, all patients are alive and have remained free of metastasis and recurrence.

CONCLUSION: Duodenal well-differentiated endocrine tumors less than 1.0 cm in diameter have a risk of lymphovascular invasion, invasion of the muscularis, and lymph node metastasis, irrespective of procedural problems.

Keywords: Duodenal well-differentiated endocrine tumors, Endoscopic resection, Surgical operation