Brief Article
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World J Gastroenterol. Sep 21, 2010; 16(35): 4476-4482
Published online Sep 21, 2010. doi: 10.3748/wjg.v16.i35.4476
HOGG1 polymorphism in atrophic gastritis and gastric cancer after Helicobacter pylori eradication
Lei-Min Sun, Yan Shang, Ya-Min Zeng, Yan-Yong Deng, Jian-Feng Cheng
Lei-Min Sun, Yan Shang, Ya-Min Zeng, Yan-Yong Deng, Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Ya-Min Zeng, the First People’ Hospital of Xiaoshan District, Hangzhou 311200, Zhejiang Province, China
Jian-Feng Cheng, Department of Gastroenterology, Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, United States
Author contributions: Sun LM performed the whole study and wrote the manuscript; Shang Y, Zeng YM and Deng YY performed the study; Cheng JF supervised the study, did the statistical analysis and wrote the manuscript.
Supported by The grants from the Education Department of Zhejiang Province, China, No. Y200803495; Zhejiang Provincial Administration of Traditional Chinese Medicine, China, No. 2008CA058; Qianjiang Talent Project of Science and Technology, China, No. 2008R10022
Correspondence to: Jian-Feng Cheng, MD, PhD, Department of Gastroenterology, Internal Medicine, Virginia Commonwealth University, 1101 E Marshall Street, Richmond, VA 23298, United States. jcheng794@gmail.com
Telephone: +1-804-8280601 Fax: +1-804-8282037
Received: February 26, 2010
Revised: June 5, 2010
Accepted: June 12, 2010
Published online: September 21, 2010
Abstract

AIM: To investigate the association between Ser326Cys human oxoguanine glycosylase 1 (hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori (H. pylori) eradication.

METHODS: A total of 488 subjects (73 patients with gastric cancer, 160 with atrophic gastritis after H. pylori eradication and 255 controls) were prospectively collected. Polymerase chain reaction-restriction fragment length polymorphism analysis was performed to distinguish hOGG1 Ser326Cys polymorphism. Statistical analysis was conducted by two-sample t test for continuous variables and χ2 test for categorical variables. Logistic regression models were used to find the risk factors for gastric cancer and atrophic gastritis.

RESULTS: Neither the hOGG1 Ser/Cys nor the Cys/Cys genotype was associated with gastric cancer. Compared with the Ser/Ser genotype, odds ratio (OR) for Ser/Cys was 0.96, (95% CI: 0.51-1.84) and OR for Cys/Cys was 1.1 (95% CI: 0.48-2.1). No association was detected between hOGG1 polymorphism and Lauren type of gastric cancer (P = 0.61) either. However, Ser/Cys and Cys/Cys were significantly associated with atrophic gastritis with OR: 1.76 for Ser/Cys (95% CI: 1.03-3.0) and 2.38 for Cys/Cys (95% CI: 1.34-4.23). After controlling for age, gender, smoking and alcohol, there were still significant associations with OR: 2.05 for Ser/Cys (95% CI: 1.14-3.68) and 2.76 for Cys/Cys (95% CI: 1.47-5.18).

CONCLUSION: HOGG1 polymorphisms (Cys/Cys and Ser/Cys) are associated with atrophic gastritis. No significant association is detected between hOGG1 polymorphisms (Cys/Cys or Ser/Cys) and gastric cancer.

Keywords: Human oxoguanine glycosylase 1 polymorphism, Atrophic gastritis, Gastric cancer