Adrych K, Smoczynski M, Stojek M, Sledzinski T, Slominska E, Goyke E, Smolenski RT, Swierczynski J. Decreased serum essential and aromatic amino acids in patients with chronic pancreatitis. World J Gastroenterol 2010; 16(35): 4422-4427 [PMID: 20845509 DOI: 10.3748/wjg.v16.i35.4422]
Corresponding Author of This Article
Julian Swierczynski, Professor, Department of Biochemistry, Medical University of Gdansk, ul. Debinki 1, 80-211 Gdansk, Poland. juls@gumed.edu.pl
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Brief Article
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World J Gastroenterol. Sep 21, 2010; 16(35): 4422-4427 Published online Sep 21, 2010. doi: 10.3748/wjg.v16.i35.4422
Decreased serum essential and aromatic amino acids in patients with chronic pancreatitis
Krystian Adrych, Marian Smoczynski, Magdalena Stojek, Tomasz Sledzinski, Ewa Slominska, Elzbieta Goyke, Ryszard Tomasz Smolenski, Julian Swierczynski
Krystian Adrych, Marian Smoczynski, Magdalena Stojek, Department of Gastroenterology and Hepatology, Medical University of Gdansk, 80-952 Gdansk, Poland
Tomasz Sledzinski, Department of Pharmaceutical Biochemistry, Medical University of Gdansk, 80-211 Gdansk, Poland
Ewa Slominska, Elzbieta Goyke, Ryszard Tomasz Smolenski, Julian Swierczynski, Department of Biochemistry, Medical University of Gdansk, 80-211 Gdansk, Poland
Author contributions: Swierczynski J designed the research; Adrych K, Smoczynski M and Stojek M treated the patients and collected material and clinical data from the patients; Smolenski RT, Slominska E and Goyke E performed the research; Smolenski RT, Slominska E and Sledzinski T analysed the data; Swierczynski J, Adrych K, Stojek M and Sledzinski T wrote the paper.
Supported by Ministry of Sciences and Higher Education Grant ST-41 and ST-43
Correspondence to: Julian Swierczynski, Professor, Department of Biochemistry, Medical University of Gdansk, ul. Debinki 1, 80-211 Gdansk, Poland. juls@gumed.edu.pl
Telephone: +48-58-3491462 Fax: +48-58-3491465
Received: April 4, 2010 Revised: June 28, 2010 Accepted: July 5, 2010 Published online: September 21, 2010
Abstract
AIM: To investigate the influence of chronic pancreatitis (CP) on serum concentrations of amino acids.
METHODS: Thirty-five male patients with alcoholic CP and 21 healthy male subjects were examined. Serum concentrations of amino acids were assayed by ion-pair high-performance liquid chromatography with mass detection.
RESULTS: Serum glutamate concentration was increased in CP patients as compared to controls. In contrast, serum concentrations of glutamine, histidine, tyrosine, proline, tryptophan and threonine were significantly decreased in CP patients. A trend towards decreasing concentrations of serum lysine, alanine, methionine and valine as well as for total serum amino acids was observed. The sum of aromatic and the sum of essential amino acid concentrations were significantly lower in CP patients than in controls.
CONCLUSION: CP leads to decreased serum concentrations of several amino acids, such as essential and aromatic serum amino acids, most likely due to decreased exocrine function.
