Brief Article
Copyright ©2010 Baishideng. All rights reserved
World J Gastroenterol. Aug 14, 2010; 16(30): 3841-3846
Published online Aug 14, 2010. doi: 10.3748/wjg.v16.i30.3841
Helicobacter pylori infection concomitant with metabolic syndrome further increase risk of colorectal adenomas
Ying-Lung Lin, Jui-Kun Chiang, Shih-Min Lin, Chih-En Tseng
Ying-Lung Lin, Jui-Kun Chiang, Department of Family Medicine, Buddhist Tzu-Chi Dalin General Hospital, Chiayi 62247, Taiwan, China
Shih-Min Lin, Department of Biological Sciences, University of Waikato, Hamilton 3216, New Zealand
Chih-En Tseng, Department of Anatomic Pathology, Buddhist Dalin Tzu Chi General Hospital, Chiayi 62247, Taiwan, China; School of Medicine, Buddhist Tzu Chi University, Hualien 97004, Taiwan, China
Author contributions: Lin YL and Tseng CE designed this study, drafted and revised the manuscript and made gave approval of the final version; Chiang JK and Lin SM collected, statistically analyzed and interpreted the data.
Supported by Buddhist Dalin Tzu Chi General Hospital
Correspondence to: Chih-En Tseng, MD, Department of Anatomic Pathology, Buddhist Dalin Tzu Chi General Hospital, 2, Min-Sheng Road, Dalin, Chiayi 62247, Taiwan, China.
Telephone: +886-5-2648000 Fax: +886-5-2648999
Received: April 4, 2010
Revised: May 10, 2010
Accepted: May 17, 2010
Published online: August 14, 2010

AIM: To investigate the association of colorectal adenomas with both Helicobacter pylori (H. pylori) infection and metabolic syndrome.

METHODS: Using a cross-sectional hospital-based study, we analyzed physical examination data from 9311 healthy subjects with overnight physical examinations performed between January 2004 and December 2006. Examined data included gender, age, life style, anthropometric measurements, blood pressure, biochemical and hematological studies, H. pylori infection detected by esophagogastroduodenoscopy and biopsy urease tests, and colorectal adenomas detected with a complete total colonoscopy.

RESULTS: The prevalence values for H. pylori infection, metabolic syndrome, and colorectal adenoma were 39.2%, 18.7%, and 20.7%, respectively. Colorectal adenoma risk factors included male gender [odd ratio (OR): 2.005, 95% confidence interval (CI): 1.740-2.310, P < 0.001], advanced age (OR: 1.046, 95% CI: 1.040-1.052, P < 0.001), smoking (OR: 1.377, 95% CI: 1.146-1.654, P = 0.001), increased body fat (OR: 1.016, 95% CI: 1.007-1.026, P = 0.001), higher white blood cell count (OR: 1.038, 95% CI: 1.005-1.073, P = 0.025), H. pylori infection (OR: 1.366, 95% CI: 1.230-1.517, P < 0.001), and metabolic syndrome (OR: 1.408, 95% CI: 1.231-1.610, P < 0.001). In addition, concomitant H. pylori infection with metabolic syndrome further increased the probability of colorectal adenomas.

CONCLUSION: Our study revealed H. pylori infection with concomitant metabolic syndrome might further increase the risk of colorectal adenomas.

Keywords: Biopsy urease test, Colorectal adenoma, Colorectal cancer, Helicobacter pylori, Metabolic syndrome